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Evolution, Chance, and Aging

Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of knowledge concerning the life histories of diverse spe...

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Detalles Bibliográficos
Autores principales: Frankel, Stewart, Rogina, Blanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458753/
https://www.ncbi.nlm.nih.gov/pubmed/34567083
http://dx.doi.org/10.3389/fgene.2021.733184
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author Frankel, Stewart
Rogina, Blanka
author_facet Frankel, Stewart
Rogina, Blanka
author_sort Frankel, Stewart
collection PubMed
description Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of knowledge concerning the life histories of diverse species. Assimilating all relevant data into a framework for the evolution of aging promises to significantly advance the field. We propose extensions of some key concepts to provide greater precision when applying these concepts to age-structured contexts. Secondary or byproduct effects of mutations are proposed as an important factor affecting survival patterns, including effects that may operate in small populations subject to genetic drift, widening the possibilities for mutation accumulation and pleiotropy. Molecular and genetic studies have indicated a diverse array of mechanisms that can modify aging and mortality rates, while transcriptome data indicate a high level of tissue and species specificity for genes affected by aging. The diversity of mechanisms and gene effects that can contribute to the pattern of aging in different organisms may mirror the complex evolutionary processes behind aging.
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spelling pubmed-84587532021-09-24 Evolution, Chance, and Aging Frankel, Stewart Rogina, Blanka Front Genet Genetics Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of knowledge concerning the life histories of diverse species. Assimilating all relevant data into a framework for the evolution of aging promises to significantly advance the field. We propose extensions of some key concepts to provide greater precision when applying these concepts to age-structured contexts. Secondary or byproduct effects of mutations are proposed as an important factor affecting survival patterns, including effects that may operate in small populations subject to genetic drift, widening the possibilities for mutation accumulation and pleiotropy. Molecular and genetic studies have indicated a diverse array of mechanisms that can modify aging and mortality rates, while transcriptome data indicate a high level of tissue and species specificity for genes affected by aging. The diversity of mechanisms and gene effects that can contribute to the pattern of aging in different organisms may mirror the complex evolutionary processes behind aging. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458753/ /pubmed/34567083 http://dx.doi.org/10.3389/fgene.2021.733184 Text en Copyright © 2021 Frankel and Rogina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Frankel, Stewart
Rogina, Blanka
Evolution, Chance, and Aging
title Evolution, Chance, and Aging
title_full Evolution, Chance, and Aging
title_fullStr Evolution, Chance, and Aging
title_full_unstemmed Evolution, Chance, and Aging
title_short Evolution, Chance, and Aging
title_sort evolution, chance, and aging
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458753/
https://www.ncbi.nlm.nih.gov/pubmed/34567083
http://dx.doi.org/10.3389/fgene.2021.733184
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