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Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men

Introduction: The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations. Purpose: The present study compared changes in acute oxidat...

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Autores principales: de Lima, Fabio Rocha, Marin, Douglas Popp, Ferreira, Letícia Torres, Sousa Filho, Celso Pereira Batista, Astorino, Todd Anthony, Prestes, Jonato, Marquezi, Marcelo Luis, Otton, Rosemari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458755/
https://www.ncbi.nlm.nih.gov/pubmed/34566685
http://dx.doi.org/10.3389/fphys.2021.720773
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author de Lima, Fabio Rocha
Marin, Douglas Popp
Ferreira, Letícia Torres
Sousa Filho, Celso Pereira Batista
Astorino, Todd Anthony
Prestes, Jonato
Marquezi, Marcelo Luis
Otton, Rosemari
author_facet de Lima, Fabio Rocha
Marin, Douglas Popp
Ferreira, Letícia Torres
Sousa Filho, Celso Pereira Batista
Astorino, Todd Anthony
Prestes, Jonato
Marquezi, Marcelo Luis
Otton, Rosemari
author_sort de Lima, Fabio Rocha
collection PubMed
description Introduction: The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations. Purpose: The present study compared changes in acute oxidative stress and markers of apoptosis in immune cells before and after 8 weeks of low-load RT with total or partial blood flow restriction (BFR) versus high-load traditional RT. Methods: Twenty-seven untrained men were randomly divided into three groups: traditional RT [75% one-repetition maximum (1-RM)], RT with partial (20% 1-RM), and total BFR (20% 1-RM). Over an 8-week period, participants performed six sets of arm curls until failure with 90 seconds of recovery for 3 days/week. Blood samples were obtained before and after the first and last training sessions. Results: Data indicated that all training groups showed similar increases in muscular strength (p < 0.001), reduction in mitochondrial membrane potential (MMP) after exercise in neutrophils (p < 0.001), and increase in caspase-3 activity after exercise (p < 0.001). Traditional RT and total BFR showed increased plasma lipid peroxidation (p < 0.001) and protein carbonyls (p < 0.001) and lower levels of reduced glutathione (GSH) (p < 0.001) after exercise. No change was observed in oxidative stress biomarkers in response to partial BFR (p > 0.05). Conclusion: Data show that RT with partial BFR can increase muscular strength but still does not augment biomarkers of oxidative stress in untrained men. In addition, RT with total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis versus traditional RT.
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spelling pubmed-84587552021-09-24 Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men de Lima, Fabio Rocha Marin, Douglas Popp Ferreira, Letícia Torres Sousa Filho, Celso Pereira Batista Astorino, Todd Anthony Prestes, Jonato Marquezi, Marcelo Luis Otton, Rosemari Front Physiol Physiology Introduction: The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations. Purpose: The present study compared changes in acute oxidative stress and markers of apoptosis in immune cells before and after 8 weeks of low-load RT with total or partial blood flow restriction (BFR) versus high-load traditional RT. Methods: Twenty-seven untrained men were randomly divided into three groups: traditional RT [75% one-repetition maximum (1-RM)], RT with partial (20% 1-RM), and total BFR (20% 1-RM). Over an 8-week period, participants performed six sets of arm curls until failure with 90 seconds of recovery for 3 days/week. Blood samples were obtained before and after the first and last training sessions. Results: Data indicated that all training groups showed similar increases in muscular strength (p < 0.001), reduction in mitochondrial membrane potential (MMP) after exercise in neutrophils (p < 0.001), and increase in caspase-3 activity after exercise (p < 0.001). Traditional RT and total BFR showed increased plasma lipid peroxidation (p < 0.001) and protein carbonyls (p < 0.001) and lower levels of reduced glutathione (GSH) (p < 0.001) after exercise. No change was observed in oxidative stress biomarkers in response to partial BFR (p > 0.05). Conclusion: Data show that RT with partial BFR can increase muscular strength but still does not augment biomarkers of oxidative stress in untrained men. In addition, RT with total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis versus traditional RT. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458755/ /pubmed/34566685 http://dx.doi.org/10.3389/fphys.2021.720773 Text en Copyright © 2021 de Lima, Marin, Ferreira, Sousa Filho, Astorino, Prestes, Marquezi and Otton. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
de Lima, Fabio Rocha
Marin, Douglas Popp
Ferreira, Letícia Torres
Sousa Filho, Celso Pereira Batista
Astorino, Todd Anthony
Prestes, Jonato
Marquezi, Marcelo Luis
Otton, Rosemari
Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title_full Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title_fullStr Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title_full_unstemmed Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title_short Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
title_sort effect of resistance training with total and partial blood flow restriction on biomarkers of oxidative stress and apoptosis in untrained men
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458755/
https://www.ncbi.nlm.nih.gov/pubmed/34566685
http://dx.doi.org/10.3389/fphys.2021.720773
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