Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma

PURPOSE: Over 90% of uveal melanomas harbor pathogenic variants of the GNAQ or GNA11 genes that activate survival pathways. As previous studies found that Ras-mutated cell lines were vulnerable to a combination of survival pathway inhibitors and the histone-deacetylase inhibitor romidepsin, we inves...

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Detalles Bibliográficos
Autores principales: Patel, Ruchi P., Thomas, Joanna R., Curt, Katherine M., Fitzsimmons, Christina M., Batista, Pedro J., Bates, Susan E., Gottesman, Michael M., Robey, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Anatomy and Pathology/Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458781/
https://www.ncbi.nlm.nih.gov/pubmed/34533562
http://dx.doi.org/10.1167/iovs.62.12.16

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