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Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy
PURPOSE: The Slc4a11 knock out (KO) mouse model recapitulates the human disease phenotype associated with congenital hereditary endothelial dystrophy (CHED). Increased mitochondrial reactive oxygen species (ROS) in the Slc4a11 KO mouse model is a major cause of edema and endothelial cell loss. Here,...
Autores principales: | Shyam, Rajalekshmy, Ogando, Diego G., Choi, Moonjung, Liton, Paloma B., Bonanno, Joseph A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458782/ https://www.ncbi.nlm.nih.gov/pubmed/34533563 http://dx.doi.org/10.1167/iovs.62.12.15 |
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