Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions

Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging,...

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Autores principales: Cao, Xiukai, Wang, Shan, Ge, Ling, Zhang, Weibo, Huang, Jinlin, Sun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458813/
https://www.ncbi.nlm.nih.gov/pubmed/34568472
http://dx.doi.org/10.3389/fvets.2021.693641
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author Cao, Xiukai
Wang, Shan
Ge, Ling
Zhang, Weibo
Huang, Jinlin
Sun, Wei
author_facet Cao, Xiukai
Wang, Shan
Ge, Ling
Zhang, Weibo
Huang, Jinlin
Sun, Wei
author_sort Cao, Xiukai
collection PubMed
description Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging, drug resistance, tumorigenesis, and phenotypic variations of plants and animals. Here we review the current knowledge about eccDNA in category, biogenesis, recognition, and functions. We also provide perspectives on the potential implications of eccDNA in life science.
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spelling pubmed-84588132021-09-24 Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions Cao, Xiukai Wang, Shan Ge, Ling Zhang, Weibo Huang, Jinlin Sun, Wei Front Vet Sci Veterinary Science Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging, drug resistance, tumorigenesis, and phenotypic variations of plants and animals. Here we review the current knowledge about eccDNA in category, biogenesis, recognition, and functions. We also provide perspectives on the potential implications of eccDNA in life science. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458813/ /pubmed/34568472 http://dx.doi.org/10.3389/fvets.2021.693641 Text en Copyright © 2021 Cao, Wang, Ge, Zhang, Huang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Cao, Xiukai
Wang, Shan
Ge, Ling
Zhang, Weibo
Huang, Jinlin
Sun, Wei
Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_full Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_fullStr Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_full_unstemmed Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_short Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_sort extrachromosomal circular dna: category, biogenesis, recognition, and functions
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458813/
https://www.ncbi.nlm.nih.gov/pubmed/34568472
http://dx.doi.org/10.3389/fvets.2021.693641
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