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Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a malignant tumor of the nasopharynx mainly characterized by geographic distribution and EBV infection. Metabolic reprogramming, one of the cancer hallmarks, has been frequently reported in NPCs to adapt to internal energy demands and external environmental pressure...

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Autores principales: Huang, Huimei, Li, Shisheng, Tang, Qinglai, Zhu, Gangcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458828/
https://www.ncbi.nlm.nih.gov/pubmed/34566954
http://dx.doi.org/10.3389/fimmu.2021.680955
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author Huang, Huimei
Li, Shisheng
Tang, Qinglai
Zhu, Gangcai
author_facet Huang, Huimei
Li, Shisheng
Tang, Qinglai
Zhu, Gangcai
author_sort Huang, Huimei
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a malignant tumor of the nasopharynx mainly characterized by geographic distribution and EBV infection. Metabolic reprogramming, one of the cancer hallmarks, has been frequently reported in NPCs to adapt to internal energy demands and external environmental pressures. Inevitably, the metabolic reprogramming within the tumor cell will lead to a decreased pH value and diverse nutritional supplements in the tumor-infiltrating micro-environment incorporating immune cells, fibroblasts, and endothelial cells. Accumulated evidence indicates that metabolic reprogramming derived from NPC cells may facilitate cancer progression and immunosuppression by cell-cell communications with their surrounding immune cells. This review presents the dysregulated metabolism processes, including glucose, fatty acid, amino acid, nucleotide metabolism, and their mutual interactions in NPC. Moreover, the potential connections between reprogrammed metabolism, tumor immunity, and associated therapy would be discussed in this review. Accordingly, the development of targets on the interactions between metabolic reprogramming and immune cells may provide assistances to overcome the current treatment resistance in NPC patients.
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spelling pubmed-84588282021-09-24 Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma Huang, Huimei Li, Shisheng Tang, Qinglai Zhu, Gangcai Front Immunol Immunology Nasopharyngeal carcinoma (NPC) is a malignant tumor of the nasopharynx mainly characterized by geographic distribution and EBV infection. Metabolic reprogramming, one of the cancer hallmarks, has been frequently reported in NPCs to adapt to internal energy demands and external environmental pressures. Inevitably, the metabolic reprogramming within the tumor cell will lead to a decreased pH value and diverse nutritional supplements in the tumor-infiltrating micro-environment incorporating immune cells, fibroblasts, and endothelial cells. Accumulated evidence indicates that metabolic reprogramming derived from NPC cells may facilitate cancer progression and immunosuppression by cell-cell communications with their surrounding immune cells. This review presents the dysregulated metabolism processes, including glucose, fatty acid, amino acid, nucleotide metabolism, and their mutual interactions in NPC. Moreover, the potential connections between reprogrammed metabolism, tumor immunity, and associated therapy would be discussed in this review. Accordingly, the development of targets on the interactions between metabolic reprogramming and immune cells may provide assistances to overcome the current treatment resistance in NPC patients. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458828/ /pubmed/34566954 http://dx.doi.org/10.3389/fimmu.2021.680955 Text en Copyright © 2021 Huang, Li, Tang and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Huimei
Li, Shisheng
Tang, Qinglai
Zhu, Gangcai
Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title_full Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title_fullStr Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title_full_unstemmed Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title_short Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
title_sort metabolic reprogramming and immune evasion in nasopharyngeal carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458828/
https://www.ncbi.nlm.nih.gov/pubmed/34566954
http://dx.doi.org/10.3389/fimmu.2021.680955
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