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Low Molar Mass Dextran: One-Step Synthesis With Dextransucrase by Site-Directed Mutagenesis and its Potential of Iron-Loading

Iron dextran is a common anti-anemia drug, and it requires low molar mass dextran as substrate. In this work, we selected 11 amino acid residues in domain A/B of DSR-MΔ2 within a 5-angstrom distance from sucrose for site-directed mutagenesis by molecular docking. Mutation of Q634 did not affect the...

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Detalles Bibliográficos
Autores principales:	Wang, Tingting, Jiang, Zhiming, Wang, Yiya, Wu, Hao, Fang, Yan, Dong, Weiliang, Wu, Bin, Ma, Jiangfeng, Jiang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458854/ https://www.ncbi.nlm.nih.gov/pubmed/34568303 http://dx.doi.org/10.3389/fbioe.2021.747602

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