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Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties
Based on the phase separation phenomenon in micro-droplets, polymer-lipid Janus particles were prepared on a microfluidic flow focusing chip. Phase separation of droplets was caused by solvent volatilization and Janus morphology was formed under the action of interfacial tension. Because phase chang...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458873/ https://www.ncbi.nlm.nih.gov/pubmed/34568306 http://dx.doi.org/10.3389/fbioe.2021.756758 |
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author | Feng, Zi-Yi Liu, Tao-Tao Sang, Zhen-Tao Lin, Zhen-Sheng Su, Xin Sun, Xiao-Ting Yang, Hua-Zhe Wang, Ting Guo, Shu |
author_facet | Feng, Zi-Yi Liu, Tao-Tao Sang, Zhen-Tao Lin, Zhen-Sheng Su, Xin Sun, Xiao-Ting Yang, Hua-Zhe Wang, Ting Guo, Shu |
author_sort | Feng, Zi-Yi |
collection | PubMed |
description | Based on the phase separation phenomenon in micro-droplets, polymer-lipid Janus particles were prepared on a microfluidic flow focusing chip. Phase separation of droplets was caused by solvent volatilization and Janus morphology was formed under the action of interfacial tension. Because phase change from solid to liquid of the lipid hemisphere could be triggered by physiological temperature, the lipid hemisphere could be used for rapid release of drugs. While the polymer we selected was pH sensitive that the polymer hemisphere could degrade under acidic conditions, making it possible to release drugs in a specific pH environment, such as tumor tissues. Janus particles with different structures were obtained by changing the experimental conditions. To widen the application range of the particles, fatty alcohol and fatty acid-based phase change materials were also employed to prepare the particles, such as 1-tetradecanol, 1-hexadecanol and lauric acid. The melting points of these substances are higher than the physiological temperature, which can be applied in fever triggered drug release or in thermotherapy. The introduction of poly (lactic-co-glycolic acid) enabled the formation of multicompartment particles with three distinct materials. With different degradation properties of each compartment, the particles generated in this work may find applications in programmed and sequential drug release triggered by multiple stimuli. |
format | Online Article Text |
id | pubmed-8458873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84588732021-09-24 Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties Feng, Zi-Yi Liu, Tao-Tao Sang, Zhen-Tao Lin, Zhen-Sheng Su, Xin Sun, Xiao-Ting Yang, Hua-Zhe Wang, Ting Guo, Shu Front Bioeng Biotechnol Bioengineering and Biotechnology Based on the phase separation phenomenon in micro-droplets, polymer-lipid Janus particles were prepared on a microfluidic flow focusing chip. Phase separation of droplets was caused by solvent volatilization and Janus morphology was formed under the action of interfacial tension. Because phase change from solid to liquid of the lipid hemisphere could be triggered by physiological temperature, the lipid hemisphere could be used for rapid release of drugs. While the polymer we selected was pH sensitive that the polymer hemisphere could degrade under acidic conditions, making it possible to release drugs in a specific pH environment, such as tumor tissues. Janus particles with different structures were obtained by changing the experimental conditions. To widen the application range of the particles, fatty alcohol and fatty acid-based phase change materials were also employed to prepare the particles, such as 1-tetradecanol, 1-hexadecanol and lauric acid. The melting points of these substances are higher than the physiological temperature, which can be applied in fever triggered drug release or in thermotherapy. The introduction of poly (lactic-co-glycolic acid) enabled the formation of multicompartment particles with three distinct materials. With different degradation properties of each compartment, the particles generated in this work may find applications in programmed and sequential drug release triggered by multiple stimuli. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458873/ /pubmed/34568306 http://dx.doi.org/10.3389/fbioe.2021.756758 Text en Copyright © 2021 Feng, Liu, Sang, Lin, Su, Sun, Yang, Wang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Feng, Zi-Yi Liu, Tao-Tao Sang, Zhen-Tao Lin, Zhen-Sheng Su, Xin Sun, Xiao-Ting Yang, Hua-Zhe Wang, Ting Guo, Shu Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title | Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title_full | Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title_fullStr | Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title_full_unstemmed | Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title_short | Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties |
title_sort | microfluidic preparation of janus microparticles with temperature and ph triggered degradation properties |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458873/ https://www.ncbi.nlm.nih.gov/pubmed/34568306 http://dx.doi.org/10.3389/fbioe.2021.756758 |
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