Association of miR-146a and miR196a2 genotype with susceptibility to idiopathic recurrent pregnancy loss in Iranian women: A case-control study

BACKGROUND: Recurrent pregnancy loss (RPL) is the most common complaint of pregnancy in females with a prevalence of 5%. Numerous documents have shown that single nucleotide polymorphisms are able to change miRNA transcription and/or maturation, which may alter the incidence of disorders such as RPL. OBJECTIVE: To assess the relationship of miR-146aC [Formula: see text] G (rs2910164) and miR-196a2T [Formula: see text] C (rs11614913) with RPL susceptibility in Iranian women. MATERIALS AND METHODS: Blood samples were collected from 214 women who had experienced at least two consecutive spontaneous miscarriages (case) and 147 normal individuals without a history of miscarriage (control). MiR-146aC [Formula: see text] G and miR-196a2T [Formula: see text] C genotypes were evaluated via the restriction fragment length polymorphism technique. RESULTS: The genotypes incidence did not show a significant difference in pre-miR-146aC [Formula: see text] G polymorphism CC vs CG + GG (p = 0.854; OR = 0.933; 95% CI) and CC + CG vs GG (p = 0.282; OR = 1.454; 95% CI). Also, no significant difference was observed between pre-miR-196a2T [Formula: see text] C polymorphism TT vs TC + CC (p = 0.862; OR = 0.938; 95% CI) and TT + TC vs CC and (p = 0.291; OR = 1.462; 95% CI) in both the case and control groups. CONCLUSION: The results showed that although the distribution of miR-146aC [Formula: see text] G and miR-196a2T [Formula: see text] C was different between the unknown RPL and control groups, these variances were not statistically significant.