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Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions
Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function. The neurobiological mechanism of schizophrenia associated with heredity remains unknown. Recently, the development of trans-scale and multi-omics methods t...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458928/ https://www.ncbi.nlm.nih.gov/pubmed/34566604 http://dx.doi.org/10.3389/fnhum.2021.720239 |
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author | Zhao, Shu-Wan Xu, Xian Wang, Xian-Yang Yan, Tian-Cai Cao, Yang Yan, Qing-Hong Chen, Kun Jin, Yin-Chuan Zhang, Ya-Hong Yin, Hong Cui, Long-Biao |
author_facet | Zhao, Shu-Wan Xu, Xian Wang, Xian-Yang Yan, Tian-Cai Cao, Yang Yan, Qing-Hong Chen, Kun Jin, Yin-Chuan Zhang, Ya-Hong Yin, Hong Cui, Long-Biao |
author_sort | Zhao, Shu-Wan |
collection | PubMed |
description | Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function. The neurobiological mechanism of schizophrenia associated with heredity remains unknown. Recently, the development of trans-scale and multi-omics methods that integrate gene and imaging information sheds new light on the nature of schizophrenia. In this article, we summarized the results of brain structural and functional changes related to the specific single-nucleotide polymorphisms (SNPs) in the past decade, and the SNPs were divided into non-coding regions and coding regions, respectively. It is hoped that the relationship between SNPs and cerebral alterations can be displayed more clearly and intuitively, so as to provide fresh approaches for the discovery of potential biomarkers and the development of clinical accurate individualized treatment decision-making. |
format | Online Article Text |
id | pubmed-8458928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84589282021-09-24 Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions Zhao, Shu-Wan Xu, Xian Wang, Xian-Yang Yan, Tian-Cai Cao, Yang Yan, Qing-Hong Chen, Kun Jin, Yin-Chuan Zhang, Ya-Hong Yin, Hong Cui, Long-Biao Front Hum Neurosci Human Neuroscience Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function. The neurobiological mechanism of schizophrenia associated with heredity remains unknown. Recently, the development of trans-scale and multi-omics methods that integrate gene and imaging information sheds new light on the nature of schizophrenia. In this article, we summarized the results of brain structural and functional changes related to the specific single-nucleotide polymorphisms (SNPs) in the past decade, and the SNPs were divided into non-coding regions and coding regions, respectively. It is hoped that the relationship between SNPs and cerebral alterations can be displayed more clearly and intuitively, so as to provide fresh approaches for the discovery of potential biomarkers and the development of clinical accurate individualized treatment decision-making. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458928/ /pubmed/34566604 http://dx.doi.org/10.3389/fnhum.2021.720239 Text en Copyright © 2021 Zhao, Xu, Wang, Yan, Cao, Yan, Chen, Jin, Zhang, Yin and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Zhao, Shu-Wan Xu, Xian Wang, Xian-Yang Yan, Tian-Cai Cao, Yang Yan, Qing-Hong Chen, Kun Jin, Yin-Chuan Zhang, Ya-Hong Yin, Hong Cui, Long-Biao Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title | Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title_full | Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title_fullStr | Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title_full_unstemmed | Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title_short | Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions |
title_sort | shaping the trans-scale properties of schizophrenia via cerebral alterations on magnetic resonance imaging and single-nucleotide polymorphisms of coding and non-coding regions |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458928/ https://www.ncbi.nlm.nih.gov/pubmed/34566604 http://dx.doi.org/10.3389/fnhum.2021.720239 |
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