GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6

Transient receptor potential canonical (TRPC) channels, as important membrane proteins regulating intracellular calcium (Ca(2+)(i)) signaling, are involved in a variety of physiological and pathological processes. Activation and regulation of TRPC are more dependent on membrane or intracellular sign...

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Detalles Bibliográficos
Autores principales: Yang, Pei-Lin, Li, Xing-Hua, Wang, Jin, Ma, Xue-Fei, Zhou, Bo-Ying, Jiao, Yuan-Feng, Wang, Wen-Hui, Cao, Peng, Zhu, Michael Xi, Li, Pei-Wang, Xiao, Zhi-Hong, Li, Chang-Zhu, Guo, Chang-Run, Lei, Yun-Tao, Yu, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458982/
https://www.ncbi.nlm.nih.gov/pubmed/34461094
http://dx.doi.org/10.1016/j.jbc.2021.101125

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