Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in KCNA1-Associated Episodic Ataxia and a Comprehensive Review of the Literature

Introduction: Among genetic paroxysmal movement disorders, variants in ion channel coding genes constitute a major subgroup. Loss-of-function (LOF) variants in KCNA1, the gene coding for K(V)1.1 channels, are associated with episodic ataxia type 1 (EA1), characterized by seconds to minutes-lasting a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lauxmann, Stephan, Sonnenberg, Lukas, Koch, Nils A., Bosselmann, Christian, Winter, Natalie, Schwarz, Niklas, Wuttke, Thomas V., Hedrich, Ulrike B. S., Liu, Yuanyuan, Lerche, Holger, Benda, Jan, Kegele, Josua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459024/
https://www.ncbi.nlm.nih.gov/pubmed/34566847
http://dx.doi.org/10.3389/fneur.2021.703970

Ejemplares similares

Ejemplares similares