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Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents

The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that...

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Autores principales: Sahlan, Muhamad, Rizka Alia Hapsari, Nur, Diah Pratami, Kartika, Cahya Khayrani, Apriliana, Lischer, Kenny, Alhazmi, Alaa, Mohammedsaleh, Zuhair M., Shater, Abdullah F., Saleh, Fayez M., Alsanie, Walaa F., Sayed, Samy, Gaber, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459154/
https://www.ncbi.nlm.nih.gov/pubmed/34588856
http://dx.doi.org/10.1016/j.sjbs.2021.08.022
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author Sahlan, Muhamad
Rizka Alia Hapsari, Nur
Diah Pratami, Kartika
Cahya Khayrani, Apriliana
Lischer, Kenny
Alhazmi, Alaa
Mohammedsaleh, Zuhair M.
Shater, Abdullah F.
Saleh, Fayez M.
Alsanie, Walaa F.
Sayed, Samy
Gaber, Ahmed
author_facet Sahlan, Muhamad
Rizka Alia Hapsari, Nur
Diah Pratami, Kartika
Cahya Khayrani, Apriliana
Lischer, Kenny
Alhazmi, Alaa
Mohammedsaleh, Zuhair M.
Shater, Abdullah F.
Saleh, Fayez M.
Alsanie, Walaa F.
Sayed, Samy
Gaber, Ahmed
author_sort Sahlan, Muhamad
collection PubMed
description The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that contain in propolis. Most researchers claim that flavonoid can be used to protect the liver. The aim of this study was to test the hepatoprotective effect of flavonoid in propolis from South Sulawesi against doxorubicin and epirubicin. The experiment included male Sprague dawley rats divided into nine groups. The rats received the microcapsule propolis or the quercetin orally for 15 days. The hepatotoxicity was promoted by injection epirubicin and doxorubicin (i.v.) with a cumulative dose of 9 mg/kg. In this study, total polyphenol and flavonoid tests of propolis have been carried out, there were 1.1% polyphenols and 2.7% flavonoids, the antioxidant activity tests showed IC50 value of 9849 ppm and LCMS/MS tests supported the presence of phenolic compounds in propolis from South Sulawesi. Liver parameter was measured and the results showed that the propolis 200 mg/kg group produced the lowest ALT and had potential protective effect against doxorubicin and epirubicin-induced hepatotoxicity.
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spelling pubmed-84591542021-09-28 Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents Sahlan, Muhamad Rizka Alia Hapsari, Nur Diah Pratami, Kartika Cahya Khayrani, Apriliana Lischer, Kenny Alhazmi, Alaa Mohammedsaleh, Zuhair M. Shater, Abdullah F. Saleh, Fayez M. Alsanie, Walaa F. Sayed, Samy Gaber, Ahmed Saudi J Biol Sci Original Article The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that contain in propolis. Most researchers claim that flavonoid can be used to protect the liver. The aim of this study was to test the hepatoprotective effect of flavonoid in propolis from South Sulawesi against doxorubicin and epirubicin. The experiment included male Sprague dawley rats divided into nine groups. The rats received the microcapsule propolis or the quercetin orally for 15 days. The hepatotoxicity was promoted by injection epirubicin and doxorubicin (i.v.) with a cumulative dose of 9 mg/kg. In this study, total polyphenol and flavonoid tests of propolis have been carried out, there were 1.1% polyphenols and 2.7% flavonoids, the antioxidant activity tests showed IC50 value of 9849 ppm and LCMS/MS tests supported the presence of phenolic compounds in propolis from South Sulawesi. Liver parameter was measured and the results showed that the propolis 200 mg/kg group produced the lowest ALT and had potential protective effect against doxorubicin and epirubicin-induced hepatotoxicity. Elsevier 2021-10 2021-08-13 /pmc/articles/PMC8459154/ /pubmed/34588856 http://dx.doi.org/10.1016/j.sjbs.2021.08.022 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Sahlan, Muhamad
Rizka Alia Hapsari, Nur
Diah Pratami, Kartika
Cahya Khayrani, Apriliana
Lischer, Kenny
Alhazmi, Alaa
Mohammedsaleh, Zuhair M.
Shater, Abdullah F.
Saleh, Fayez M.
Alsanie, Walaa F.
Sayed, Samy
Gaber, Ahmed
Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title_full Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title_fullStr Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title_full_unstemmed Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title_short Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
title_sort potential hepatoprotective effects of flavonoids contained in propolis from south sulawesi against chemotherapy agents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459154/
https://www.ncbi.nlm.nih.gov/pubmed/34588856
http://dx.doi.org/10.1016/j.sjbs.2021.08.022
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