TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of gut epithelial barrier function. This may be due to their a...

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Detalles Bibliográficos
Autores principales: Woznicki, Jerzy A., Saini, Nisha, Flood, Peter, Rajaram, Subhasree, Lee, Ciaran M., Stamou, Panagiota, Skowyra, Agnieszka, Bustamante-Garrido, Milan, Regazzoni, Karine, Crawford, Nyree, McDade, Simon S., Longley, Daniel B., Aza-Blanc, Pedro, Shanahan, Fergus, Zulquernain, Syed A., McCarthy, Jane, Melgar, Silvia, McRae, Bradford L., Nally, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459343/
https://www.ncbi.nlm.nih.gov/pubmed/34556638
http://dx.doi.org/10.1038/s41419-021-04151-3

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