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Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming

Kupffer cells (KCs) are highly abundant, intravascular, liver-resident macrophages known for their scavenger and phagocytic functions. KCs can also present antigens to CD8(+) T cells and promote either tolerance or effector differentiation, but the mechanisms underlying these discrepant outcomes are...

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Detalles Bibliográficos
Autores principales: De Simone, Giorgia, Andreata, Francesco, Bleriot, Camille, Fumagalli, Valeria, Laura, Chiara, Garcia-Manteiga, José M., Di Lucia, Pietro, Gilotto, Stefano, Ficht, Xenia, De Ponti, Federico F., Bono, Elisa B., Giustini, Leonardo, Ambrosi, Gioia, Mainetti, Marta, Zordan, Paola, Bénéchet, Alexandre P., Ravà, Micol, Chakarov, Svetoslav, Moalli, Federica, Bajenoff, Marc, Guidotti, Luca G., Ginhoux, Florent, Iannacone, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459394/
https://www.ncbi.nlm.nih.gov/pubmed/34469774
http://dx.doi.org/10.1016/j.immuni.2021.05.005