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MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail
BACKGROUND: MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse models have demonstrated both MDM2 and MDMX are individually essential for p53...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459461/ https://www.ncbi.nlm.nih.gov/pubmed/34551723 http://dx.doi.org/10.1186/s12860-021-00385-3 |