Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons

BACKGROUND: Homozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson’s disease. In homozygosis, these mutations impair the activity of β-glucocerebrosidase, the en...

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Detalles Bibliográficos
Autores principales: Brunialti, Electra, Villa, Alessandro, Mekhaeil, Marianna, Mornata, Federica, Vegeto, Elisabetta, Maggi, Adriana, Di Monte, Donato A., Ciana, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459568/
https://www.ncbi.nlm.nih.gov/pubmed/34551802
http://dx.doi.org/10.1186/s12974-021-02272-2

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