Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult

Thrombotic microangiopathies (TMA) are disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microthrombi leading to organ dysfunction. Atypical hemolytic uremic syndrome (aHUS) is a rare subtype of TMA mediated by complement dysregulation. We present a case of a 59-yea...

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Detalles Bibliográficos
Autores principales: Alhabhbeh, Ammar, Fatima, Zainab, Thomas, Akesh, Cook, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459801/
https://www.ncbi.nlm.nih.gov/pubmed/34589371
http://dx.doi.org/10.7759/cureus.18184
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author Alhabhbeh, Ammar
Fatima, Zainab
Thomas, Akesh
Cook, Christopher
author_facet Alhabhbeh, Ammar
Fatima, Zainab
Thomas, Akesh
Cook, Christopher
author_sort Alhabhbeh, Ammar
collection PubMed
description Thrombotic microangiopathies (TMA) are disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microthrombi leading to organ dysfunction. Atypical hemolytic uremic syndrome (aHUS) is a rare subtype of TMA mediated by complement dysregulation. We present a case of a 59-year-old female who presented with acute kidney injury and mild thrombocytopenia but with normal hemoglobin. We highlight the importance of prompt diagnosis of aHUS and initiating appropriate treatment with eculizumab.
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spelling pubmed-84598012021-09-28 Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult Alhabhbeh, Ammar Fatima, Zainab Thomas, Akesh Cook, Christopher Cureus Internal Medicine Thrombotic microangiopathies (TMA) are disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microthrombi leading to organ dysfunction. Atypical hemolytic uremic syndrome (aHUS) is a rare subtype of TMA mediated by complement dysregulation. We present a case of a 59-year-old female who presented with acute kidney injury and mild thrombocytopenia but with normal hemoglobin. We highlight the importance of prompt diagnosis of aHUS and initiating appropriate treatment with eculizumab. Cureus 2021-09-22 /pmc/articles/PMC8459801/ /pubmed/34589371 http://dx.doi.org/10.7759/cureus.18184 Text en Copyright © 2021, Alhabhbeh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alhabhbeh, Ammar
Fatima, Zainab
Thomas, Akesh
Cook, Christopher
Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title_full Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title_fullStr Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title_full_unstemmed Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title_short Rare Presentation of Atypical Hemolytic Uremic Syndrome in an Adult
title_sort rare presentation of atypical hemolytic uremic syndrome in an adult
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459801/
https://www.ncbi.nlm.nih.gov/pubmed/34589371
http://dx.doi.org/10.7759/cureus.18184
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