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Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines

Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene...

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Autores principales: Gonçalves, Natália dos Santos, de Mello, Tamires Maria Silva Pereira, Mizuno, Cássia Suemi, Haider, Saqlain, dos Santos, Raquel Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459827/
https://www.ncbi.nlm.nih.gov/pubmed/34555143
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0477
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author Gonçalves, Natália dos Santos
de Mello, Tamires Maria Silva Pereira
Mizuno, Cássia Suemi
Haider, Saqlain
dos Santos, Raquel Alves
author_facet Gonçalves, Natália dos Santos
de Mello, Tamires Maria Silva Pereira
Mizuno, Cássia Suemi
Haider, Saqlain
dos Santos, Raquel Alves
author_sort Gonçalves, Natália dos Santos
collection PubMed
description Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis- and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested that the genotoxicity of cis- and trans-TMS is involved in the reduction of cellular proliferation of MCF-7 and MCF-10A cells, but notably, such antiproliferative effects are more pronounced for cis- than trans-TMS.
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spelling pubmed-84598272021-10-01 Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines Gonçalves, Natália dos Santos de Mello, Tamires Maria Silva Pereira Mizuno, Cássia Suemi Haider, Saqlain dos Santos, Raquel Alves Genet Mol Biol Mutagenesis Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis- and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested that the genotoxicity of cis- and trans-TMS is involved in the reduction of cellular proliferation of MCF-7 and MCF-10A cells, but notably, such antiproliferative effects are more pronounced for cis- than trans-TMS. Sociedade Brasileira de Genética 2021-09-22 /pmc/articles/PMC8459827/ /pubmed/34555143 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0477 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Mutagenesis
Gonçalves, Natália dos Santos
de Mello, Tamires Maria Silva Pereira
Mizuno, Cássia Suemi
Haider, Saqlain
dos Santos, Raquel Alves
Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title_full Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title_fullStr Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title_full_unstemmed Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title_short Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
title_sort cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in mcf-7 and mcf-10a cell lines
topic Mutagenesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459827/
https://www.ncbi.nlm.nih.gov/pubmed/34555143
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0477
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