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Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy

Anticancer drugs play an important role in reducing mortality rates and increasing life expectancy in cancer patients. Treatments include monotherapy and/or a combination of radiation therapy, chemotherapy, hormone therapy, or immunotherapy. Despite great advances in drug development, some of these...

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Autores principales: Gabani, Mohanad, Castañeda, Diana, Nguyen, Quynh My, Choi, Soo-Kyoung, Chen, Cheng, Mapara, Ayesha, Kassan, Adam, Gonzalez, Alexis A, Khataei, Tahsin, Ait-Aissa, Karima, Kassan, Modar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459919/
https://www.ncbi.nlm.nih.gov/pubmed/34589374
http://dx.doi.org/10.7759/cureus.18194
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author Gabani, Mohanad
Castañeda, Diana
Nguyen, Quynh My
Choi, Soo-Kyoung
Chen, Cheng
Mapara, Ayesha
Kassan, Adam
Gonzalez, Alexis A
Khataei, Tahsin
Ait-Aissa, Karima
Kassan, Modar
author_facet Gabani, Mohanad
Castañeda, Diana
Nguyen, Quynh My
Choi, Soo-Kyoung
Chen, Cheng
Mapara, Ayesha
Kassan, Adam
Gonzalez, Alexis A
Khataei, Tahsin
Ait-Aissa, Karima
Kassan, Modar
author_sort Gabani, Mohanad
collection PubMed
description Anticancer drugs play an important role in reducing mortality rates and increasing life expectancy in cancer patients. Treatments include monotherapy and/or a combination of radiation therapy, chemotherapy, hormone therapy, or immunotherapy. Despite great advances in drug development, some of these treatments have been shown to induce cardiotoxicity directly affecting heart function and structure, as well as accelerating the development of cardiovascular disease. Such side effects restrict treatment options and can negatively affect disease management. Consequently, when managing cancer patients, it is vital to understand the mechanisms causing cardiotoxicity to better monitor heart function, develop preventative measures against cardiotoxicity, and treat heart failure when it occurs in this patient population. This review discusses the role and mechanism of major chemotherapy agents with principal cardiovascular complications in cancer patients.
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spelling pubmed-84599192021-09-28 Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy Gabani, Mohanad Castañeda, Diana Nguyen, Quynh My Choi, Soo-Kyoung Chen, Cheng Mapara, Ayesha Kassan, Adam Gonzalez, Alexis A Khataei, Tahsin Ait-Aissa, Karima Kassan, Modar Cureus Cardiology Anticancer drugs play an important role in reducing mortality rates and increasing life expectancy in cancer patients. Treatments include monotherapy and/or a combination of radiation therapy, chemotherapy, hormone therapy, or immunotherapy. Despite great advances in drug development, some of these treatments have been shown to induce cardiotoxicity directly affecting heart function and structure, as well as accelerating the development of cardiovascular disease. Such side effects restrict treatment options and can negatively affect disease management. Consequently, when managing cancer patients, it is vital to understand the mechanisms causing cardiotoxicity to better monitor heart function, develop preventative measures against cardiotoxicity, and treat heart failure when it occurs in this patient population. This review discusses the role and mechanism of major chemotherapy agents with principal cardiovascular complications in cancer patients. Cureus 2021-09-22 /pmc/articles/PMC8459919/ /pubmed/34589374 http://dx.doi.org/10.7759/cureus.18194 Text en Copyright © 2021, Gabani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Gabani, Mohanad
Castañeda, Diana
Nguyen, Quynh My
Choi, Soo-Kyoung
Chen, Cheng
Mapara, Ayesha
Kassan, Adam
Gonzalez, Alexis A
Khataei, Tahsin
Ait-Aissa, Karima
Kassan, Modar
Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title_full Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title_fullStr Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title_full_unstemmed Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title_short Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
title_sort association of cardiotoxicity with doxorubicin and trastuzumab: a double-edged sword in chemotherapy
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459919/
https://www.ncbi.nlm.nih.gov/pubmed/34589374
http://dx.doi.org/10.7759/cureus.18194
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