Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. Pseudomonas aeruginosa expresses a phospholipase, ExoU that triggers pathological host cell necrosis through a poorly characterized pathway....

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Detalles Bibliográficos
Autores principales: Bagayoko, Salimata, Leon-Icaza, Stephen Adonai, Pinilla, Miriam, Hessel, Audrey, Santoni, Karin, Péricat, David, Bordignon, Pierre-Jean, Moreau, Flavie, Eren, Elif, Boyancé, Aurélien, Naser, Emmanuelle, Lefèvre, Lise, Berrone, Céline, Iakobachvili, Nino, Metais, Arnaud, Rombouts, Yoann, Lugo-Villarino, Geanncarlo, Coste, Agnès, Attrée, Ina, Frank, Dara W., Clevers, Hans, Peters, Peter J., Cougoule, Céline, Planès, Rémi, Meunier, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460005/
https://www.ncbi.nlm.nih.gov/pubmed/34516571
http://dx.doi.org/10.1371/journal.ppat.1009927

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