Immunological exhaustion: How to make a disparate concept operational?

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to cl...

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Detalles Bibliográficos
Autores principales: Kaminski, Hannah, Lemoine, Maël, Pradeu, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460019/
https://www.ncbi.nlm.nih.gov/pubmed/34555119
http://dx.doi.org/10.1371/journal.ppat.1009892
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author Kaminski, Hannah
Lemoine, Maël
Pradeu, Thomas
author_facet Kaminski, Hannah
Lemoine, Maël
Pradeu, Thomas
author_sort Kaminski, Hannah
collection PubMed
description In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
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spelling pubmed-84600192021-09-24 Immunological exhaustion: How to make a disparate concept operational? Kaminski, Hannah Lemoine, Maël Pradeu, Thomas PLoS Pathog Review In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational. Public Library of Science 2021-09-23 /pmc/articles/PMC8460019/ /pubmed/34555119 http://dx.doi.org/10.1371/journal.ppat.1009892 Text en © 2021 Kaminski et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Kaminski, Hannah
Lemoine, Maël
Pradeu, Thomas
Immunological exhaustion: How to make a disparate concept operational?
title Immunological exhaustion: How to make a disparate concept operational?
title_full Immunological exhaustion: How to make a disparate concept operational?
title_fullStr Immunological exhaustion: How to make a disparate concept operational?
title_full_unstemmed Immunological exhaustion: How to make a disparate concept operational?
title_short Immunological exhaustion: How to make a disparate concept operational?
title_sort immunological exhaustion: how to make a disparate concept operational?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460019/
https://www.ncbi.nlm.nih.gov/pubmed/34555119
http://dx.doi.org/10.1371/journal.ppat.1009892
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