Cargando…

Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up

ChondroFiller gel is an absorbable collagen implant. It serves as a protective cover for the cartilage defects, allowing chondrocyte migration into the lesion. The implant consists of collagen (Type I) and is derived from veterinary monitored rats. This study evaluates the use of ChondroFiller gel i...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazek, Jacek, Gnatowski, Maciej, Salas, Antonio Porthos, O’Donnell, John M, Domżalski, Marcin, Radzimowski, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460160/
https://www.ncbi.nlm.nih.gov/pubmed/34567597
http://dx.doi.org/10.1093/jhps/hnab002
_version_ 1784571682275459072
author Mazek, Jacek
Gnatowski, Maciej
Salas, Antonio Porthos
O’Donnell, John M
Domżalski, Marcin
Radzimowski, Jakub
author_facet Mazek, Jacek
Gnatowski, Maciej
Salas, Antonio Porthos
O’Donnell, John M
Domżalski, Marcin
Radzimowski, Jakub
author_sort Mazek, Jacek
collection PubMed
description ChondroFiller gel is an absorbable collagen implant. It serves as a protective cover for the cartilage defects, allowing chondrocyte migration into the lesion. The implant consists of collagen (Type I) and is derived from veterinary monitored rats. This study evaluates the use of ChondroFiller gel in the treatment of cartilage lesions during hip joint arthroscopy. A prospective study was conducted on a group of 26 adult patients. All patients had an existing femoroacetabular impingement together with acetabular cartilage lesions >2 cm(2). All patients underwent hip arthroscopic surgery and the lesions were treated using ChondroFiller gel. The cartilage tissue healing was evaluated postoperatively using MRI. A total of 26 patients, including 5 females and 21 males, all with articular cartilage lesions, were included in the study. Cartilage healing conditions were evaluated for all patients, and the difference between pre- and post-surgery conditions was statistically significant. The follow-up scores have been acquired from 21 out of initial 26 patients (2 were disqualified after receiving THR, 3 could not be reached by researchers) after 3, 4 and 5 years consecutively with 17/21 patients having good/excellent results. The use of ChondroFiller gel during arthroscopy of the hip for acetabular cartilage lesions is an effective treatment technique. Encouraging long-term results have been observed, but further research on larger group of patient is required to better assess the full value of this technique. Patients with pre-existing osteoarthritis (Tönnis 2–3) have poor results.
format Online
Article
Text
id pubmed-8460160
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-84601602021-09-24 Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up Mazek, Jacek Gnatowski, Maciej Salas, Antonio Porthos O’Donnell, John M Domżalski, Marcin Radzimowski, Jakub J Hip Preserv Surg Research Articles ChondroFiller gel is an absorbable collagen implant. It serves as a protective cover for the cartilage defects, allowing chondrocyte migration into the lesion. The implant consists of collagen (Type I) and is derived from veterinary monitored rats. This study evaluates the use of ChondroFiller gel in the treatment of cartilage lesions during hip joint arthroscopy. A prospective study was conducted on a group of 26 adult patients. All patients had an existing femoroacetabular impingement together with acetabular cartilage lesions >2 cm(2). All patients underwent hip arthroscopic surgery and the lesions were treated using ChondroFiller gel. The cartilage tissue healing was evaluated postoperatively using MRI. A total of 26 patients, including 5 females and 21 males, all with articular cartilage lesions, were included in the study. Cartilage healing conditions were evaluated for all patients, and the difference between pre- and post-surgery conditions was statistically significant. The follow-up scores have been acquired from 21 out of initial 26 patients (2 were disqualified after receiving THR, 3 could not be reached by researchers) after 3, 4 and 5 years consecutively with 17/21 patients having good/excellent results. The use of ChondroFiller gel during arthroscopy of the hip for acetabular cartilage lesions is an effective treatment technique. Encouraging long-term results have been observed, but further research on larger group of patient is required to better assess the full value of this technique. Patients with pre-existing osteoarthritis (Tönnis 2–3) have poor results. Oxford University Press 2021-07-31 /pmc/articles/PMC8460160/ /pubmed/34567597 http://dx.doi.org/10.1093/jhps/hnab002 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Mazek, Jacek
Gnatowski, Maciej
Salas, Antonio Porthos
O’Donnell, John M
Domżalski, Marcin
Radzimowski, Jakub
Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title_full Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title_fullStr Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title_full_unstemmed Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title_short Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
title_sort arthroscopic utilization of chondrofiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460160/
https://www.ncbi.nlm.nih.gov/pubmed/34567597
http://dx.doi.org/10.1093/jhps/hnab002
work_keys_str_mv AT mazekjacek arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup
AT gnatowskimaciej arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup
AT salasantonioporthos arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup
AT odonnelljohnm arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup
AT domzalskimarcin arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup
AT radzimowskijakub arthroscopicutilizationofchondrofillergelforthetreatmentofhiparticularcartilagedefectsacohortstudywith12to60monthfollowup