A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the ac...

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Detalles Bibliográficos
Autores principales: Patil, Gajanan S, Kinatukara, Priyadarshan, Mondal, Sudipta, Shambhavi, Sakshi, Patel, Ketan D, Pramanik, Surabhi, Dubey, Noopur, Narasimhan, Subhash, Madduri, Murali Krishna, Pal, Biswajit, Gokhale, Rajesh S, Sankaranarayanan, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460268/
https://www.ncbi.nlm.nih.gov/pubmed/34490847
http://dx.doi.org/10.7554/eLife.70067

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