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PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin

PURPOSE: To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas. METHODS: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed...

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Detalles Bibliográficos
Autores principales:	Quigley, Neil Gerard, Steiger, Katja, Hoberück, Sebastian, Czech, Norbert, Zierke, Maximilian Alexander, Kossatz, Susanne, Pretze, Marc, Richter, Frauke, Weichert, Wilko, Pox, Christian, Kotzerke, Jörg, Notni, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460406/ https://www.ncbi.nlm.nih.gov/pubmed/34559266 http://dx.doi.org/10.1007/s00259-021-05559-x

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