D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation

The D614G mutation in the spike protein of SARS-CoV-2 alters the fitness of the virus, leading to the dominant form observed in the COVID-19 pandemic. However, the molecular basis of the mechanism by which this mutation enhances fitness is not clear. Here we demonstrated by cryo-electron microscopy...

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Detalles Bibliográficos
Autores principales: Yang, Tzu-Jing, Yu, Pei-Yu, Chang, Yuan-Chih, Hsu, Shang-Te Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460419/
https://www.ncbi.nlm.nih.gov/pubmed/34563540
http://dx.doi.org/10.1016/j.jbc.2021.101238

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