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Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study

BACKGROUND: The association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations. METHODS: We evaluated the fixed dataset...

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Autores principales: Kurita, Hiroshi, Motoki, Noriko, Inaba, Yuji, Misawa, Yuka, Ohira, Satoshi, Kanai, Makoto, Tsukahara, Teruomi, Nomiyama, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460444/
https://www.ncbi.nlm.nih.gov/pubmed/33230193
http://dx.doi.org/10.1038/s41390-020-01274-9
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author Kurita, Hiroshi
Motoki, Noriko
Inaba, Yuji
Misawa, Yuka
Ohira, Satoshi
Kanai, Makoto
Tsukahara, Teruomi
Nomiyama, Tetsuo
author_facet Kurita, Hiroshi
Motoki, Noriko
Inaba, Yuji
Misawa, Yuka
Ohira, Satoshi
Kanai, Makoto
Tsukahara, Teruomi
Nomiyama, Tetsuo
author_sort Kurita, Hiroshi
collection PubMed
description BACKGROUND: The association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations. METHODS: We evaluated the fixed dataset of a large national birth cohort study including 73,595 mothers with a singleton live birth. Information regarding the alcohol consumption of mothers was obtained from self-reported questionnaires. Physicians assessed for 6 major congenital malformations (congenital heart defects [CHDs], male genital abnormalities, limb defects, cleft lip and/or cleft palate [orofacial clefts (OFC)], severe brain abnormalities, and gastrointestinal obstructions) up to 1 month after birth. Multiple logistic regression analysis was performed to identify associations between maternal alcohol consumption during pregnancy and each malformation. RESULTS: The prevalence of maternal drinking in early pregnancy and until the second/third trimester was 46.6% and 2.8%, respectively. The onset of CHD was inversely associated with mothers who quit drinking during early pregnancy (OR 0.85, 95% CI 0.74–0.98). There was no remarkable impact of maternal drinking habit status on the other congenital malformations after adjustment for covariates. CONCLUSIONS: Maternal alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital malformations of interest. IMPACT: This large-scale Japanese cohort study revealed that no teratogenic associations were found between maternal retrospective reports of periconceptional alcohol consumption and congenital malformations after adjustment for covariates. This is the first nationwide birth cohort study in Japan to assess the effect of maternal alcohol consumption during pregnancy on major congenital malformations. Our finding indicated that maternal low-to-moderate alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital heart defects, male genital abnormalities, limb defects, orofacial clefts, severe brain abnormalities, or gastrointestinal obstructions.
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spelling pubmed-84604442021-10-07 Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study Kurita, Hiroshi Motoki, Noriko Inaba, Yuji Misawa, Yuka Ohira, Satoshi Kanai, Makoto Tsukahara, Teruomi Nomiyama, Tetsuo Pediatr Res Population Study Article BACKGROUND: The association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations. METHODS: We evaluated the fixed dataset of a large national birth cohort study including 73,595 mothers with a singleton live birth. Information regarding the alcohol consumption of mothers was obtained from self-reported questionnaires. Physicians assessed for 6 major congenital malformations (congenital heart defects [CHDs], male genital abnormalities, limb defects, cleft lip and/or cleft palate [orofacial clefts (OFC)], severe brain abnormalities, and gastrointestinal obstructions) up to 1 month after birth. Multiple logistic regression analysis was performed to identify associations between maternal alcohol consumption during pregnancy and each malformation. RESULTS: The prevalence of maternal drinking in early pregnancy and until the second/third trimester was 46.6% and 2.8%, respectively. The onset of CHD was inversely associated with mothers who quit drinking during early pregnancy (OR 0.85, 95% CI 0.74–0.98). There was no remarkable impact of maternal drinking habit status on the other congenital malformations after adjustment for covariates. CONCLUSIONS: Maternal alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital malformations of interest. IMPACT: This large-scale Japanese cohort study revealed that no teratogenic associations were found between maternal retrospective reports of periconceptional alcohol consumption and congenital malformations after adjustment for covariates. This is the first nationwide birth cohort study in Japan to assess the effect of maternal alcohol consumption during pregnancy on major congenital malformations. Our finding indicated that maternal low-to-moderate alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital heart defects, male genital abnormalities, limb defects, orofacial clefts, severe brain abnormalities, or gastrointestinal obstructions. Nature Publishing Group US 2020-11-23 2021 /pmc/articles/PMC8460444/ /pubmed/33230193 http://dx.doi.org/10.1038/s41390-020-01274-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Population Study Article
Kurita, Hiroshi
Motoki, Noriko
Inaba, Yuji
Misawa, Yuka
Ohira, Satoshi
Kanai, Makoto
Tsukahara, Teruomi
Nomiyama, Tetsuo
Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title_full Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title_fullStr Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title_full_unstemmed Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title_short Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study
title_sort maternal alcohol consumption and risk of offspring with congenital malformation: the japan environment and children’s study
topic Population Study Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460444/
https://www.ncbi.nlm.nih.gov/pubmed/33230193
http://dx.doi.org/10.1038/s41390-020-01274-9
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