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CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

An emerging mechanism of ubiquitylation involves partnering of two distinct E3 ligases. In the best-characterized E3-E3 pathways, ARIH-family RING-between-RING (RBR) E3s ligate ubiquitin to substrates of neddylated cullin-RING E3s. The E3 ARIH2 has been implicated in ubiquitylation of substrates of...

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Detalles Bibliográficos
Autores principales:	Kostrhon, Sebastian, Prabu, J. Rajan, Baek, Kheewoong, Horn-Ghetko, Daniel, von Gronau, Susanne, Klügel, Maren, Basquin, Jérôme, Alpi, Arno F., Schulman, Brenda A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460447/ https://www.ncbi.nlm.nih.gov/pubmed/34518685 http://dx.doi.org/10.1038/s41589-021-00858-8

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