Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Melanomas driven by loss of the NF1 tumor suppressor have a high risk of treatment failure and effective therapies have not been developed. Here we show that loss-of-function mutations of nf1 and pten result in aggressive melanomas in zebrafish, representing the first animal model of NF1-mutant mela...

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Detalles Bibliográficos
Autores principales: He, Shuning, Zimmerman, Mark W., Layden, Hillary M., Berezovskaya, Alla, Etchin, Julia, Martel, Megan W., Thurston, Grace, Jing, Chang-Bin, van Rooijen, Ellen, Kaufman, Charles K., Rodig, Scott J., Zon, Leonard I., Patton, E. Elizabeth, Mansour, Marc R., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460449/
https://www.ncbi.nlm.nih.gov/pubmed/34331013
http://dx.doi.org/10.1038/s41388-021-01926-y

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