Senescence and associated blood–brain barrier alterations in vitro

Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and c...

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Autores principales: Salvador, Ellaine, Burek, Malgorzata, Löhr, Mario, Nagai, Michiaki, Hagemann, Carsten, Förster, Carola Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460501/
https://www.ncbi.nlm.nih.gov/pubmed/34043058
http://dx.doi.org/10.1007/s00418-021-01992-z
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author Salvador, Ellaine
Burek, Malgorzata
Löhr, Mario
Nagai, Michiaki
Hagemann, Carsten
Förster, Carola Y.
author_facet Salvador, Ellaine
Burek, Malgorzata
Löhr, Mario
Nagai, Michiaki
Hagemann, Carsten
Förster, Carola Y.
author_sort Salvador, Ellaine
collection PubMed
description Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.
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spelling pubmed-84605012021-10-07 Senescence and associated blood–brain barrier alterations in vitro Salvador, Ellaine Burek, Malgorzata Löhr, Mario Nagai, Michiaki Hagemann, Carsten Förster, Carola Y. Histochem Cell Biol Short Communication Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within. Springer Berlin Heidelberg 2021-05-27 2021 /pmc/articles/PMC8460501/ /pubmed/34043058 http://dx.doi.org/10.1007/s00418-021-01992-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Salvador, Ellaine
Burek, Malgorzata
Löhr, Mario
Nagai, Michiaki
Hagemann, Carsten
Förster, Carola Y.
Senescence and associated blood–brain barrier alterations in vitro
title Senescence and associated blood–brain barrier alterations in vitro
title_full Senescence and associated blood–brain barrier alterations in vitro
title_fullStr Senescence and associated blood–brain barrier alterations in vitro
title_full_unstemmed Senescence and associated blood–brain barrier alterations in vitro
title_short Senescence and associated blood–brain barrier alterations in vitro
title_sort senescence and associated blood–brain barrier alterations in vitro
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460501/
https://www.ncbi.nlm.nih.gov/pubmed/34043058
http://dx.doi.org/10.1007/s00418-021-01992-z
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