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ASL expression in ALDH1A1(+) neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype
Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expressed in dopaminergic neurons in the substantia nig...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460544/ https://www.ncbi.nlm.nih.gov/pubmed/34417872 http://dx.doi.org/10.1007/s00439-021-02345-5 |