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Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magneti...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460624/ https://www.ncbi.nlm.nih.gov/pubmed/34556757 http://dx.doi.org/10.1038/s41598-021-98484-w |
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author | Kato, Natsuko Muraga, Kanako Hirata, Yoshinori Shindo, Akihiro Matsuura, Keita Ii, Yuichiro Shiga, Mariko Tabei, Ken-ichi Satoh, Masayuki Fujita, Satoshi Fukuma, Tomoyuki Kagawa, Yoshihiko Fujii, Eitaro Umino, Maki Maeda, Masayuki Sakuma, Hajime Ito, Masaaki Tomimoto, Hidekazu |
author_facet | Kato, Natsuko Muraga, Kanako Hirata, Yoshinori Shindo, Akihiro Matsuura, Keita Ii, Yuichiro Shiga, Mariko Tabei, Ken-ichi Satoh, Masayuki Fujita, Satoshi Fukuma, Tomoyuki Kagawa, Yoshihiko Fujii, Eitaro Umino, Maki Maeda, Masayuki Sakuma, Hajime Ito, Masaaki Tomimoto, Hidekazu |
author_sort | Kato, Natsuko |
collection | PubMed |
description | Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) and neuropsychological assessments (66 patients) were performed 1–3 days (baseline) and 6 months after ablation. Immediately after ablation, diffusion-weighted MRI and 3-dimensional double inversion recovery (3D-DIR) detected embolic microinfarctions in 63 patients (87.5%) and 62 patients (86.1%), respectively. After 6 months, DIR lesions disappeared in 41 patients. Microbleeds (MBs) increased by 17%, and 65% of the de novo MBs were exactly at the same location as the microinfarctions. Average Mini-Mental State Examination scores improved from 27.9 ± 2.4 to 28.5 ± 1.7 (p = 0.037), and detailed neuropsychological assessment scores showed improvement in memory, constructional, and frontal lobe functions. Ejection fraction, left atrial volume index and brain natriuretic peptide level improved from baseline to 3–6 months after ablation. Despite incidental microemboli, cognitive function was preserved 6 months after ablation. |
format | Online Article Text |
id | pubmed-8460624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84606242021-09-24 Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation Kato, Natsuko Muraga, Kanako Hirata, Yoshinori Shindo, Akihiro Matsuura, Keita Ii, Yuichiro Shiga, Mariko Tabei, Ken-ichi Satoh, Masayuki Fujita, Satoshi Fukuma, Tomoyuki Kagawa, Yoshihiko Fujii, Eitaro Umino, Maki Maeda, Masayuki Sakuma, Hajime Ito, Masaaki Tomimoto, Hidekazu Sci Rep Article Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) and neuropsychological assessments (66 patients) were performed 1–3 days (baseline) and 6 months after ablation. Immediately after ablation, diffusion-weighted MRI and 3-dimensional double inversion recovery (3D-DIR) detected embolic microinfarctions in 63 patients (87.5%) and 62 patients (86.1%), respectively. After 6 months, DIR lesions disappeared in 41 patients. Microbleeds (MBs) increased by 17%, and 65% of the de novo MBs were exactly at the same location as the microinfarctions. Average Mini-Mental State Examination scores improved from 27.9 ± 2.4 to 28.5 ± 1.7 (p = 0.037), and detailed neuropsychological assessment scores showed improvement in memory, constructional, and frontal lobe functions. Ejection fraction, left atrial volume index and brain natriuretic peptide level improved from baseline to 3–6 months after ablation. Despite incidental microemboli, cognitive function was preserved 6 months after ablation. Nature Publishing Group UK 2021-09-23 /pmc/articles/PMC8460624/ /pubmed/34556757 http://dx.doi.org/10.1038/s41598-021-98484-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kato, Natsuko Muraga, Kanako Hirata, Yoshinori Shindo, Akihiro Matsuura, Keita Ii, Yuichiro Shiga, Mariko Tabei, Ken-ichi Satoh, Masayuki Fujita, Satoshi Fukuma, Tomoyuki Kagawa, Yoshihiko Fujii, Eitaro Umino, Maki Maeda, Masayuki Sakuma, Hajime Ito, Masaaki Tomimoto, Hidekazu Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title | Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title_full | Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title_fullStr | Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title_full_unstemmed | Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title_short | Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
title_sort | brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460624/ https://www.ncbi.nlm.nih.gov/pubmed/34556757 http://dx.doi.org/10.1038/s41598-021-98484-w |
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