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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue, represent a promising treatment strategy. We report the pre-clinical efficacy of 1-methyl-2-nitroimidazole panobinosta...

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Detalles Bibliográficos
Autores principales:	Skwarska, Anna, Calder, Ewen D.D., Sneddon, Deborah, Bolland, Hannah, Odyniec, Maria L., Mistry, Ishna N., Martin, Jennifer, Folkes, Lisa K., Conway, Stuart J., Hammond, Ester M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460716/ https://www.ncbi.nlm.nih.gov/pubmed/33910023 http://dx.doi.org/10.1016/j.chembiol.2021.04.004

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