Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis

Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative capacity of beta cells might account for pancreatic endocrine insufficiency. Previously, we found that only a few pancreatic cytokeratin 5 positive (Krt5(+...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoyi, Tao, Jing, Yu, Jia, Hu, Ning, Zhang, Xuanzhe, Wang, Guirong, Feng, Jiarui, Xiong, Xingcheng, Li, Man, Chai, Dongqi, Li, Hanjun, Rong, Yuping, Tang, Zhigang, Wang, Weixing, Peng, Zhiyong, Shi, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460737/
https://www.ncbi.nlm.nih.gov/pubmed/34556631
http://dx.doi.org/10.1038/s41419-021-04160-2

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