Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification

Aims: This study concentrates on the relationship between antipsychotic drugs (APDs) and aortic calcification. Methods: All 56 patients with schizophrenia were divided into two groups according to aortic calcification index. APD equivalent dose was calculated via defined daily doses method. Results:...

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Autores principales: Zhang, Chao, Zheng, Dongdong, Feng, Weijing, Zhang, Huanji, Han, Feng, He, Wanbing, Liu, Aiting, Huang, Hui, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460775/
https://www.ncbi.nlm.nih.gov/pubmed/34568454
http://dx.doi.org/10.3389/fcvm.2021.710090
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author Zhang, Chao
Zheng, Dongdong
Feng, Weijing
Zhang, Huanji
Han, Feng
He, Wanbing
Liu, Aiting
Huang, Hui
Chen, Jie
author_facet Zhang, Chao
Zheng, Dongdong
Feng, Weijing
Zhang, Huanji
Han, Feng
He, Wanbing
Liu, Aiting
Huang, Hui
Chen, Jie
author_sort Zhang, Chao
collection PubMed
description Aims: This study concentrates on the relationship between antipsychotic drugs (APDs) and aortic calcification. Methods: All 56 patients with schizophrenia were divided into two groups according to aortic calcification index. APD equivalent dose was calculated via defined daily doses method. Results: In schizophrenia patients with higher aortic calcification index scores, APD equivalent doses were lower. APD equivalent dose was negatively related to aortic calcification index. Although equivalent APD dose in patients without olanzapine treatment was negatively related to aortic calcification index, it seems that equivalent APD dose did not associate with aortic calcification. Conclusion: Aortic calcification is negatively associated with APD dose in schizophrenia patients. Olanzapine seems to be vital to the relationship between aortic calcification and APD treatment.
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spelling pubmed-84607752021-09-25 Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification Zhang, Chao Zheng, Dongdong Feng, Weijing Zhang, Huanji Han, Feng He, Wanbing Liu, Aiting Huang, Hui Chen, Jie Front Cardiovasc Med Cardiovascular Medicine Aims: This study concentrates on the relationship between antipsychotic drugs (APDs) and aortic calcification. Methods: All 56 patients with schizophrenia were divided into two groups according to aortic calcification index. APD equivalent dose was calculated via defined daily doses method. Results: In schizophrenia patients with higher aortic calcification index scores, APD equivalent doses were lower. APD equivalent dose was negatively related to aortic calcification index. Although equivalent APD dose in patients without olanzapine treatment was negatively related to aortic calcification index, it seems that equivalent APD dose did not associate with aortic calcification. Conclusion: Aortic calcification is negatively associated with APD dose in schizophrenia patients. Olanzapine seems to be vital to the relationship between aortic calcification and APD treatment. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8460775/ /pubmed/34568454 http://dx.doi.org/10.3389/fcvm.2021.710090 Text en Copyright © 2021 Zhang, Zheng, Feng, Zhang, Han, He, Liu, Huang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhang, Chao
Zheng, Dongdong
Feng, Weijing
Zhang, Huanji
Han, Feng
He, Wanbing
Liu, Aiting
Huang, Hui
Chen, Jie
Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title_full Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title_fullStr Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title_full_unstemmed Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title_short Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification
title_sort olanzapine: association between a typical antipsychotic drug and aortic calcification
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460775/
https://www.ncbi.nlm.nih.gov/pubmed/34568454
http://dx.doi.org/10.3389/fcvm.2021.710090
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