Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal survival but the developmental timing and mechanistic importance of mitochondrial dysfunction in sporadic ALS (sALS) neurons is not fully underst...

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Detalles Bibliográficos
Autores principales: Singh, Tanisha, Jiao, Yuanyuan, Ferrando, Lisa M., Yablonska, Svitlana, Li, Fang, Horoszko, Emily C., Lacomis, David, Friedlander, Robert M., Carlisle, Diane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460779/
https://www.ncbi.nlm.nih.gov/pubmed/34556702
http://dx.doi.org/10.1038/s41598-021-97928-7

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