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Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence

Mast cells are well known to be activated via cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and regulators of both innate and adaptive immune responses against pathogens, especially in the skin and mucosal surfaces. Substantial attention has...

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Detalles Bibliográficos
Autores principales: Palma, Alejandro M., Hanes, Mark R., Marshall, Jean S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460918/
https://www.ncbi.nlm.nih.gov/pubmed/34566974
http://dx.doi.org/10.3389/fimmu.2021.718499
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author Palma, Alejandro M.
Hanes, Mark R.
Marshall, Jean S.
author_facet Palma, Alejandro M.
Hanes, Mark R.
Marshall, Jean S.
author_sort Palma, Alejandro M.
collection PubMed
description Mast cells are well known to be activated via cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and regulators of both innate and adaptive immune responses against pathogens, especially in the skin and mucosal surfaces. Substantial attention has been given to the role of mast cells in regulating T cell function either directly or indirectly through actions on dendritic cells. In contrast, the ability of mast cells to modify B cell responses has been less explored. Several lines of evidence suggest that mast cells can greatly modify B cell generation and activities. Mast cells co-localise with B cells in many tissue settings and produce substantial amounts of cytokines, such as IL-6, with profound impacts on B cell development, class-switch recombination events, and subsequent antibody production. Mast cells have also been suggested to modulate the development and functions of regulatory B cells. In this review, we discuss the critical impacts of mast cells on B cells using information from both clinical and laboratory studies and consider the implications of these findings on the host response to infections.
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spelling pubmed-84609182021-09-25 Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence Palma, Alejandro M. Hanes, Mark R. Marshall, Jean S. Front Immunol Immunology Mast cells are well known to be activated via cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and regulators of both innate and adaptive immune responses against pathogens, especially in the skin and mucosal surfaces. Substantial attention has been given to the role of mast cells in regulating T cell function either directly or indirectly through actions on dendritic cells. In contrast, the ability of mast cells to modify B cell responses has been less explored. Several lines of evidence suggest that mast cells can greatly modify B cell generation and activities. Mast cells co-localise with B cells in many tissue settings and produce substantial amounts of cytokines, such as IL-6, with profound impacts on B cell development, class-switch recombination events, and subsequent antibody production. Mast cells have also been suggested to modulate the development and functions of regulatory B cells. In this review, we discuss the critical impacts of mast cells on B cells using information from both clinical and laboratory studies and consider the implications of these findings on the host response to infections. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8460918/ /pubmed/34566974 http://dx.doi.org/10.3389/fimmu.2021.718499 Text en Copyright © 2021 Palma, Hanes and Marshall https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Palma, Alejandro M.
Hanes, Mark R.
Marshall, Jean S.
Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title_full Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title_fullStr Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title_full_unstemmed Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title_short Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence
title_sort mast cell modulation of b cell responses: an under-appreciated partnership in host defence
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460918/
https://www.ncbi.nlm.nih.gov/pubmed/34566974
http://dx.doi.org/10.3389/fimmu.2021.718499
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