Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect

Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detect...

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Autores principales: Al Maqrashi, Zainab, Sedarous, Mary, Pandey, Avinash, Ross, Catherine, Wyne, Ahraaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460932/
https://www.ncbi.nlm.nih.gov/pubmed/34703431
http://dx.doi.org/10.1159/000517658
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author Al Maqrashi, Zainab
Sedarous, Mary
Pandey, Avinash
Ross, Catherine
Wyne, Ahraaz
author_facet Al Maqrashi, Zainab
Sedarous, Mary
Pandey, Avinash
Ross, Catherine
Wyne, Ahraaz
author_sort Al Maqrashi, Zainab
collection PubMed
description Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin's lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg's effect, and its potential for prognostication.
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spelling pubmed-84609322021-10-25 Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect Al Maqrashi, Zainab Sedarous, Mary Pandey, Avinash Ross, Catherine Wyne, Ahraaz Case Rep Oncol Case Report Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin's lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg's effect, and its potential for prognostication. S. Karger AG 2021-07-30 /pmc/articles/PMC8460932/ /pubmed/34703431 http://dx.doi.org/10.1159/000517658 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Al Maqrashi, Zainab
Sedarous, Mary
Pandey, Avinash
Ross, Catherine
Wyne, Ahraaz
Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title_full Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title_fullStr Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title_full_unstemmed Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title_short Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin's Lymphoma: A Case Report and Review of the Warburg Effect
title_sort refractory hyperlactatemia and hypoglycemia in an adult with non-hodgkin's lymphoma: a case report and review of the warburg effect
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460932/
https://www.ncbi.nlm.nih.gov/pubmed/34703431
http://dx.doi.org/10.1159/000517658
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