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Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma
A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461009/ https://www.ncbi.nlm.nih.gov/pubmed/34568441 http://dx.doi.org/10.3389/fcvm.2021.676188 |
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author | Capponi, Guglielmo Giovannini, Mattia Koniari, Ioanna Mori, Francesca Rubino, Chiara Spaziani, Gaia Calabri, Giovanni Battista Favilli, Silvia Novembre, Elio Indolfi, Giuseppe De Simone, Luciano Trapani, Sandra |
author_facet | Capponi, Guglielmo Giovannini, Mattia Koniari, Ioanna Mori, Francesca Rubino, Chiara Spaziani, Gaia Calabri, Giovanni Battista Favilli, Silvia Novembre, Elio Indolfi, Giuseppe De Simone, Luciano Trapani, Sandra |
author_sort | Capponi, Guglielmo |
collection | PubMed |
description | A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function 72 hours from the beginning of the clinical manifestations, while cardiac Magnetic Resonance Imaging was performed, and coronary Computed Tomography scan revealed a myocardial bridge of a tract of the left anterior descendent coronary artery. Diagnosis of Kounis syndrome (KS) was made, a relatively novel, under-recognized clinical condition, defined as the manifestation of an acute coronary syndrome accompanied by mast cell activation and platelet aggregation involving interrelated and interacting inflammatory cells in the setting of allergic, hypersensitivity, anaphylactic or anaphylactoid insults. We described one of the first pediatric cases of KS related to anesthetic medications. In children, this syndrome has been only described in isolated case reports or small case series. Thus, it appears critical to report new cases of KS in children to increase the awareness of this disease in pediatric healthcare workers so as to enhance its early recognition and optimal therapeutic strategy. Furthermore, it appears of paramount importance the implementation of universal guidelines accepted by allergology and cardiology societies, in order to standardize the management of pediatric and adult patients with KS. Finally, a close collaboration between pediatric allergists and cardiologists seems fundamental for an optimal multidisciplinary patient care. |
format | Online Article Text |
id | pubmed-8461009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84610092021-09-25 Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma Capponi, Guglielmo Giovannini, Mattia Koniari, Ioanna Mori, Francesca Rubino, Chiara Spaziani, Gaia Calabri, Giovanni Battista Favilli, Silvia Novembre, Elio Indolfi, Giuseppe De Simone, Luciano Trapani, Sandra Front Cardiovasc Med Cardiovascular Medicine A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function 72 hours from the beginning of the clinical manifestations, while cardiac Magnetic Resonance Imaging was performed, and coronary Computed Tomography scan revealed a myocardial bridge of a tract of the left anterior descendent coronary artery. Diagnosis of Kounis syndrome (KS) was made, a relatively novel, under-recognized clinical condition, defined as the manifestation of an acute coronary syndrome accompanied by mast cell activation and platelet aggregation involving interrelated and interacting inflammatory cells in the setting of allergic, hypersensitivity, anaphylactic or anaphylactoid insults. We described one of the first pediatric cases of KS related to anesthetic medications. In children, this syndrome has been only described in isolated case reports or small case series. Thus, it appears critical to report new cases of KS in children to increase the awareness of this disease in pediatric healthcare workers so as to enhance its early recognition and optimal therapeutic strategy. Furthermore, it appears of paramount importance the implementation of universal guidelines accepted by allergology and cardiology societies, in order to standardize the management of pediatric and adult patients with KS. Finally, a close collaboration between pediatric allergists and cardiologists seems fundamental for an optimal multidisciplinary patient care. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8461009/ /pubmed/34568441 http://dx.doi.org/10.3389/fcvm.2021.676188 Text en Copyright © 2021 Capponi, Giovannini, Koniari, Mori, Rubino, Spaziani, Calabri, Favilli, Novembre, Indolfi, De Simone and Trapani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Capponi, Guglielmo Giovannini, Mattia Koniari, Ioanna Mori, Francesca Rubino, Chiara Spaziani, Gaia Calabri, Giovanni Battista Favilli, Silvia Novembre, Elio Indolfi, Giuseppe De Simone, Luciano Trapani, Sandra Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title | Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title_full | Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title_fullStr | Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title_full_unstemmed | Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title_short | Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma |
title_sort | case report: perioperative kounis syndrome in an adolescent with congenital glaucoma |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461009/ https://www.ncbi.nlm.nih.gov/pubmed/34568441 http://dx.doi.org/10.3389/fcvm.2021.676188 |
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