Cargando…
Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment
Shiyiwei Shenqi Tablet (SSTs) has been widely used for treatment of different types of cancer including breast cancer. SST has drawn more and more interest due to the low rate of side effects. The aim of this study was to investigate the metabolites in serums of breast cancer patients who received b...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461015/ https://www.ncbi.nlm.nih.gov/pubmed/34566645 http://dx.doi.org/10.3389/fphar.2021.720886 |
_version_ | 1784571885040697344 |
---|---|
author | Wan, Hong Xu, Xiaojun Yang, Xiaowei Li, Angqing Ma, Xiaopeng Xu, Aman Yuan, Xiao Wang, Wenbin Guo, Tao Luo, Guangtao He, Xiaobo Li, Wang Wang, Zhaorui Sun, Qiang Pei, Jing Guo, Yongzhen Zhu, Yong |
author_facet | Wan, Hong Xu, Xiaojun Yang, Xiaowei Li, Angqing Ma, Xiaopeng Xu, Aman Yuan, Xiao Wang, Wenbin Guo, Tao Luo, Guangtao He, Xiaobo Li, Wang Wang, Zhaorui Sun, Qiang Pei, Jing Guo, Yongzhen Zhu, Yong |
author_sort | Wan, Hong |
collection | PubMed |
description | Shiyiwei Shenqi Tablet (SSTs) has been widely used for treatment of different types of cancer including breast cancer. SST has drawn more and more interest due to the low rate of side effects. The aim of this study was to investigate the metabolites in serums of breast cancer patients who received base-line chemotherapy only or combination treatment with SST. An untargeted metabolomics method was developed to investigate the alteration of metabolism in patients’ serums using ultra-high-performance liquid chromatography/Q-exactive Orbitrap mass spectrometry. The patients were separated based on the metabolomics data, and further analyses showed that SST treatment can affect the metabolism of glucose, fatty acid, bile acid and amino acid. In particular, SST treatment significantly reduced some short peptides which are potential tumor neoantigens. This study may provide novel insights into the mechanism underlying interaction between SST and base-line chemotherapy in terms of affecting metabolic pathways and thereby changing metabolic products, which might shed new light for clinical medication. |
format | Online Article Text |
id | pubmed-8461015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84610152021-09-25 Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment Wan, Hong Xu, Xiaojun Yang, Xiaowei Li, Angqing Ma, Xiaopeng Xu, Aman Yuan, Xiao Wang, Wenbin Guo, Tao Luo, Guangtao He, Xiaobo Li, Wang Wang, Zhaorui Sun, Qiang Pei, Jing Guo, Yongzhen Zhu, Yong Front Pharmacol Pharmacology Shiyiwei Shenqi Tablet (SSTs) has been widely used for treatment of different types of cancer including breast cancer. SST has drawn more and more interest due to the low rate of side effects. The aim of this study was to investigate the metabolites in serums of breast cancer patients who received base-line chemotherapy only or combination treatment with SST. An untargeted metabolomics method was developed to investigate the alteration of metabolism in patients’ serums using ultra-high-performance liquid chromatography/Q-exactive Orbitrap mass spectrometry. The patients were separated based on the metabolomics data, and further analyses showed that SST treatment can affect the metabolism of glucose, fatty acid, bile acid and amino acid. In particular, SST treatment significantly reduced some short peptides which are potential tumor neoantigens. This study may provide novel insights into the mechanism underlying interaction between SST and base-line chemotherapy in terms of affecting metabolic pathways and thereby changing metabolic products, which might shed new light for clinical medication. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8461015/ /pubmed/34566645 http://dx.doi.org/10.3389/fphar.2021.720886 Text en Copyright © 2021 Wan, Xu, Yang, Li, Ma, Xu, Yuan, Wang, Guo, Luo, He, Li, Wang, Sun, Pei, Guo and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wan, Hong Xu, Xiaojun Yang, Xiaowei Li, Angqing Ma, Xiaopeng Xu, Aman Yuan, Xiao Wang, Wenbin Guo, Tao Luo, Guangtao He, Xiaobo Li, Wang Wang, Zhaorui Sun, Qiang Pei, Jing Guo, Yongzhen Zhu, Yong Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title | Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title_full | Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title_fullStr | Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title_full_unstemmed | Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title_short | Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment |
title_sort | metabolomics analysis reveals interaction of base-line chemotherapy and shiyiwei shenqi tablets in breast cancer treatment |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461015/ https://www.ncbi.nlm.nih.gov/pubmed/34566645 http://dx.doi.org/10.3389/fphar.2021.720886 |
work_keys_str_mv | AT wanhong metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT xuxiaojun metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT yangxiaowei metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT liangqing metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT maxiaopeng metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT xuaman metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT yuanxiao metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT wangwenbin metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT guotao metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT luoguangtao metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT hexiaobo metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT liwang metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT wangzhaorui metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT sunqiang metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT peijing metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT guoyongzhen metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment AT zhuyong metabolomicsanalysisrevealsinteractionofbaselinechemotherapyandshiyiweishenqitabletsinbreastcancertreatment |