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Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series

We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, n...

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Autores principales: Fiori, Simona, Pannek, Kerstin, Podda, Irina, Cipriani, Paola, Lorenzoni, V., Franchi, Beatrice, Pasquariello, Rosa, Guzzetta, Andrea, Cioni, Giovanni, Chilosi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461047/
https://www.ncbi.nlm.nih.gov/pubmed/34315296
http://dx.doi.org/10.1177/08830738211015800
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author Fiori, Simona
Pannek, Kerstin
Podda, Irina
Cipriani, Paola
Lorenzoni, V.
Franchi, Beatrice
Pasquariello, Rosa
Guzzetta, Andrea
Cioni, Giovanni
Chilosi, Anna
author_facet Fiori, Simona
Pannek, Kerstin
Podda, Irina
Cipriani, Paola
Lorenzoni, V.
Franchi, Beatrice
Pasquariello, Rosa
Guzzetta, Andrea
Cioni, Giovanni
Chilosi, Anna
author_sort Fiori, Simona
collection PubMed
description We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, nonspeech oral motor treatment. Speech assessment and brain MRI were performed pre- and post-treatment. The ventral (tongue/larynx) and dorsal (lips) corticobulbar tracts were reconstructed in each subject. Mean fractional anisotropy and mean diffusivity were extracted. The hand corticospinal tract was assessed as a control pathway. In both groups speech improvements paralleled changes in the left ventral corticobulbar tract fractional anisotropy. The PROMPT treated group also showed fractional anisotropy increase and mean diffusivity decrease in the left dorsal corticobulbar tract. No changes were detected in the hand tract. Our results may provide preliminary support to the possible neurobiologic effect of a multimodal speech motor treatment in childhood apraxia of speech.
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spelling pubmed-84610472021-09-25 Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series Fiori, Simona Pannek, Kerstin Podda, Irina Cipriani, Paola Lorenzoni, V. Franchi, Beatrice Pasquariello, Rosa Guzzetta, Andrea Cioni, Giovanni Chilosi, Anna J Child Neurol Original Articles We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, nonspeech oral motor treatment. Speech assessment and brain MRI were performed pre- and post-treatment. The ventral (tongue/larynx) and dorsal (lips) corticobulbar tracts were reconstructed in each subject. Mean fractional anisotropy and mean diffusivity were extracted. The hand corticospinal tract was assessed as a control pathway. In both groups speech improvements paralleled changes in the left ventral corticobulbar tract fractional anisotropy. The PROMPT treated group also showed fractional anisotropy increase and mean diffusivity decrease in the left dorsal corticobulbar tract. No changes were detected in the hand tract. Our results may provide preliminary support to the possible neurobiologic effect of a multimodal speech motor treatment in childhood apraxia of speech. SAGE Publications 2021-07-28 2021-10 /pmc/articles/PMC8461047/ /pubmed/34315296 http://dx.doi.org/10.1177/08830738211015800 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Fiori, Simona
Pannek, Kerstin
Podda, Irina
Cipriani, Paola
Lorenzoni, V.
Franchi, Beatrice
Pasquariello, Rosa
Guzzetta, Andrea
Cioni, Giovanni
Chilosi, Anna
Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title_full Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title_fullStr Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title_full_unstemmed Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title_short Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
title_sort neural changes induced by a speech motor treatment in childhood apraxia of speech: a case series
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461047/
https://www.ncbi.nlm.nih.gov/pubmed/34315296
http://dx.doi.org/10.1177/08830738211015800
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