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Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series
We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, n...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461047/ https://www.ncbi.nlm.nih.gov/pubmed/34315296 http://dx.doi.org/10.1177/08830738211015800 |
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author | Fiori, Simona Pannek, Kerstin Podda, Irina Cipriani, Paola Lorenzoni, V. Franchi, Beatrice Pasquariello, Rosa Guzzetta, Andrea Cioni, Giovanni Chilosi, Anna |
author_facet | Fiori, Simona Pannek, Kerstin Podda, Irina Cipriani, Paola Lorenzoni, V. Franchi, Beatrice Pasquariello, Rosa Guzzetta, Andrea Cioni, Giovanni Chilosi, Anna |
author_sort | Fiori, Simona |
collection | PubMed |
description | We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, nonspeech oral motor treatment. Speech assessment and brain MRI were performed pre- and post-treatment. The ventral (tongue/larynx) and dorsal (lips) corticobulbar tracts were reconstructed in each subject. Mean fractional anisotropy and mean diffusivity were extracted. The hand corticospinal tract was assessed as a control pathway. In both groups speech improvements paralleled changes in the left ventral corticobulbar tract fractional anisotropy. The PROMPT treated group also showed fractional anisotropy increase and mean diffusivity decrease in the left dorsal corticobulbar tract. No changes were detected in the hand tract. Our results may provide preliminary support to the possible neurobiologic effect of a multimodal speech motor treatment in childhood apraxia of speech. |
format | Online Article Text |
id | pubmed-8461047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-84610472021-09-25 Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series Fiori, Simona Pannek, Kerstin Podda, Irina Cipriani, Paola Lorenzoni, V. Franchi, Beatrice Pasquariello, Rosa Guzzetta, Andrea Cioni, Giovanni Chilosi, Anna J Child Neurol Original Articles We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, nonspeech oral motor treatment. Speech assessment and brain MRI were performed pre- and post-treatment. The ventral (tongue/larynx) and dorsal (lips) corticobulbar tracts were reconstructed in each subject. Mean fractional anisotropy and mean diffusivity were extracted. The hand corticospinal tract was assessed as a control pathway. In both groups speech improvements paralleled changes in the left ventral corticobulbar tract fractional anisotropy. The PROMPT treated group also showed fractional anisotropy increase and mean diffusivity decrease in the left dorsal corticobulbar tract. No changes were detected in the hand tract. Our results may provide preliminary support to the possible neurobiologic effect of a multimodal speech motor treatment in childhood apraxia of speech. SAGE Publications 2021-07-28 2021-10 /pmc/articles/PMC8461047/ /pubmed/34315296 http://dx.doi.org/10.1177/08830738211015800 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Fiori, Simona Pannek, Kerstin Podda, Irina Cipriani, Paola Lorenzoni, V. Franchi, Beatrice Pasquariello, Rosa Guzzetta, Andrea Cioni, Giovanni Chilosi, Anna Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title | Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title_full | Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title_fullStr | Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title_full_unstemmed | Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title_short | Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series |
title_sort | neural changes induced by a speech motor treatment in childhood apraxia of speech: a case series |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461047/ https://www.ncbi.nlm.nih.gov/pubmed/34315296 http://dx.doi.org/10.1177/08830738211015800 |
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