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Current Developments in Detection of Identity-by-Descent Methods and Applications

Identity-by-descent (IBD), the detection of shared segments inherited from a common ancestor, is a fundamental concept in genomics with broad applications in the characterization and analysis of genomes. While historically the concept of IBD was extensively utilized through linkage analyses and in s...

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Autores principales: Sticca, Evan L., Belbin, Gillian M., Gignoux, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461052/
https://www.ncbi.nlm.nih.gov/pubmed/34567074
http://dx.doi.org/10.3389/fgene.2021.722602
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author Sticca, Evan L.
Belbin, Gillian M.
Gignoux, Christopher R.
author_facet Sticca, Evan L.
Belbin, Gillian M.
Gignoux, Christopher R.
author_sort Sticca, Evan L.
collection PubMed
description Identity-by-descent (IBD), the detection of shared segments inherited from a common ancestor, is a fundamental concept in genomics with broad applications in the characterization and analysis of genomes. While historically the concept of IBD was extensively utilized through linkage analyses and in studies of founder populations, applications of IBD-based methods subsided during the genome-wide association study era. This was primarily due to the computational expense of IBD detection, which becomes increasingly relevant as the field moves toward the analysis of biobank-scale datasets that encompass individuals from highly diverse backgrounds. To address these computational barriers, the past several years have seen new methodological advances enabling IBD detection for datasets in the hundreds of thousands to millions of individuals, enabling novel analyses at an unprecedented scale. Here, we describe the latest innovations in IBD detection and describe opportunities for the application of IBD-based methods across a broad range of questions in the field of genomics.
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spelling pubmed-84610522021-09-25 Current Developments in Detection of Identity-by-Descent Methods and Applications Sticca, Evan L. Belbin, Gillian M. Gignoux, Christopher R. Front Genet Genetics Identity-by-descent (IBD), the detection of shared segments inherited from a common ancestor, is a fundamental concept in genomics with broad applications in the characterization and analysis of genomes. While historically the concept of IBD was extensively utilized through linkage analyses and in studies of founder populations, applications of IBD-based methods subsided during the genome-wide association study era. This was primarily due to the computational expense of IBD detection, which becomes increasingly relevant as the field moves toward the analysis of biobank-scale datasets that encompass individuals from highly diverse backgrounds. To address these computational barriers, the past several years have seen new methodological advances enabling IBD detection for datasets in the hundreds of thousands to millions of individuals, enabling novel analyses at an unprecedented scale. Here, we describe the latest innovations in IBD detection and describe opportunities for the application of IBD-based methods across a broad range of questions in the field of genomics. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8461052/ /pubmed/34567074 http://dx.doi.org/10.3389/fgene.2021.722602 Text en Copyright © 2021 Sticca, Belbin and Gignoux. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Sticca, Evan L.
Belbin, Gillian M.
Gignoux, Christopher R.
Current Developments in Detection of Identity-by-Descent Methods and Applications
title Current Developments in Detection of Identity-by-Descent Methods and Applications
title_full Current Developments in Detection of Identity-by-Descent Methods and Applications
title_fullStr Current Developments in Detection of Identity-by-Descent Methods and Applications
title_full_unstemmed Current Developments in Detection of Identity-by-Descent Methods and Applications
title_short Current Developments in Detection of Identity-by-Descent Methods and Applications
title_sort current developments in detection of identity-by-descent methods and applications
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461052/
https://www.ncbi.nlm.nih.gov/pubmed/34567074
http://dx.doi.org/10.3389/fgene.2021.722602
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