High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Tumor heterogeneity is a key reason for therapeutic failure and tumor recurrence in glioblastoma (GBM). Our chimeric antigen receptor (CAR) T cell (2173 CAR T cells) clinical trial (NCT02209376) against epidermal growth factor receptor (EGFR) variant III (EGFRvIII) demonstrated successful traffickin...

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Detalles Bibliográficos
Autores principales: Thokala, Radhika, Binder, Zev A., Yin, Yibo, Zhang, Logan, Zhang, Jiasi Vicky, Zhang, Daniel Y., Milone, Michael C., Ming, Guo-li, Song, Hongjun, O’Rourke, Donald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461175/
https://www.ncbi.nlm.nih.gov/pubmed/34568006
http://dx.doi.org/10.3389/fonc.2021.664236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461175/
https://www.ncbi.nlm.nih.gov/pubmed/34568006
http://dx.doi.org/10.3389/fonc.2021.664236

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