A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, resulting in a frameshift and the emergence of an early stop codon, rendering a truncated mature protein of 57 amino acids. The predicted protein, lacking the...

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Detalles Bibliográficos
Autores principales: Bertolio, Marcela Soledad, La Colla, Anabela, Carrea, Alejandra, Romo, Ana, Canziani, Gabriela, Echarte, Stella Maris, Campisano, Sabrina, Barletta, German Patricio, Monzon, Alexander Miguel, Rodríguez, Tania Melina, Chisari, Andrea Nancy, Dewey, Ricardo Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461249/
https://www.ncbi.nlm.nih.gov/pubmed/34568316
http://dx.doi.org/10.3389/fcell.2021.690397

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