Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment

Glioma, characterized by infiltrative growth and treatment resistance, is regarded as the most prevalent intracranial malignant tumor. Due to its poor prognosis, accumulating investigation has been performed for improvement of overall survival (OS) and progression-free survival (PFS) in glioma patie...

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Detalles Bibliográficos
Autores principales: Han, Wei, Guan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461314/
https://www.ncbi.nlm.nih.gov/pubmed/34568018
http://dx.doi.org/10.3389/fonc.2021.687362
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author Han, Wei
Guan, Wei
author_facet Han, Wei
Guan, Wei
author_sort Han, Wei
collection PubMed
description Glioma, characterized by infiltrative growth and treatment resistance, is regarded as the most prevalent intracranial malignant tumor. Due to its poor prognosis, accumulating investigation has been performed for improvement of overall survival (OS) and progression-free survival (PFS) in glioma patients. Valproic acid (VPA), one of the most common histone deacetylase inhibitors (HDACIs), has been detected to directly or synergistically exert inhibitory effects on glioma in vitro and in vivo. In this review, we generalize the latest advances of VPA in treating glioma and its underlying mechanisms and clinical implications, providing a clearer profile for clinical application of VPA as a therapeutic agent for glioma.
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spelling pubmed-84613142021-09-25 Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment Han, Wei Guan, Wei Front Oncol Oncology Glioma, characterized by infiltrative growth and treatment resistance, is regarded as the most prevalent intracranial malignant tumor. Due to its poor prognosis, accumulating investigation has been performed for improvement of overall survival (OS) and progression-free survival (PFS) in glioma patients. Valproic acid (VPA), one of the most common histone deacetylase inhibitors (HDACIs), has been detected to directly or synergistically exert inhibitory effects on glioma in vitro and in vivo. In this review, we generalize the latest advances of VPA in treating glioma and its underlying mechanisms and clinical implications, providing a clearer profile for clinical application of VPA as a therapeutic agent for glioma. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8461314/ /pubmed/34568018 http://dx.doi.org/10.3389/fonc.2021.687362 Text en Copyright © 2021 Han and Guan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Han, Wei
Guan, Wei
Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title_full Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title_fullStr Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title_full_unstemmed Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title_short Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment
title_sort valproic acid: a promising therapeutic agent in glioma treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461314/
https://www.ncbi.nlm.nih.gov/pubmed/34568018
http://dx.doi.org/10.3389/fonc.2021.687362
work_keys_str_mv AT hanwei valproicacidapromisingtherapeuticagentingliomatreatment
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