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Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study

The cholinergic system is critical in Parkinson’s disease (PD) pathology, which accounts for various clinical symptoms in PD patients. The substantia innominata (SI) provides the main source of cortical cholinergic innervation. Previous studies revealed cholinergic-related dysfunction in PD patholog...

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Autores principales: Sheng, Wenshuang, Guo, Tao, Zhou, Cheng, Wu, Jingjing, Gao, Ting, Pu, Jiali, Zhang, Baorong, Zhang, Minming, Yang, Yunjun, Guan, Xiaojun, Xu, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461333/
https://www.ncbi.nlm.nih.gov/pubmed/34566625
http://dx.doi.org/10.3389/fnagi.2021.723948
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author Sheng, Wenshuang
Guo, Tao
Zhou, Cheng
Wu, Jingjing
Gao, Ting
Pu, Jiali
Zhang, Baorong
Zhang, Minming
Yang, Yunjun
Guan, Xiaojun
Xu, Xiaojun
author_facet Sheng, Wenshuang
Guo, Tao
Zhou, Cheng
Wu, Jingjing
Gao, Ting
Pu, Jiali
Zhang, Baorong
Zhang, Minming
Yang, Yunjun
Guan, Xiaojun
Xu, Xiaojun
author_sort Sheng, Wenshuang
collection PubMed
description The cholinergic system is critical in Parkinson’s disease (PD) pathology, which accounts for various clinical symptoms in PD patients. The substantia innominata (SI) provides the main source of cortical cholinergic innervation. Previous studies revealed cholinergic-related dysfunction in PD pathology at early stage. Since PD is a progressive disorder, alterations of cholinergic system function along with the PD progression have yet to be elucidated. Seventy-nine PD patients, including thirty-five early-stage PD patients (PD-E) and forty-four middle-to-late stage PD patients (PD-M), and sixty-four healthy controls (HC) underwent brain magnetic resonance imaging and clinical assessments. We employed seed-based resting-state functional connectivity analysis to explore the cholinergic-related functional alterations. Correlation analysis was used to investigate the relationship between altered functional connectivity and the severity of motor symptoms in PD patients. Results showed that both PD-E and PD-M groups exhibited decreased functional connectivity between left SI and left frontal inferior opercularis areas and increased functional connectivity between left SI and left cingulum middle area as well as right primary motor and sensory areas when comparing with HC. At advanced stages of PD, functional connectivity in the right primary motor and sensory areas was further increased. These altered functional connectivity were also significantly correlated with the Unified Parkinson’s Disease Rating Scale motor scores. In conclusion, this study illustrated that altered cholinergic function plays an important role in the motor disruptions in PD patients both in early stage as well as during the progression of the disease.
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spelling pubmed-84613332021-09-25 Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study Sheng, Wenshuang Guo, Tao Zhou, Cheng Wu, Jingjing Gao, Ting Pu, Jiali Zhang, Baorong Zhang, Minming Yang, Yunjun Guan, Xiaojun Xu, Xiaojun Front Aging Neurosci Neuroscience The cholinergic system is critical in Parkinson’s disease (PD) pathology, which accounts for various clinical symptoms in PD patients. The substantia innominata (SI) provides the main source of cortical cholinergic innervation. Previous studies revealed cholinergic-related dysfunction in PD pathology at early stage. Since PD is a progressive disorder, alterations of cholinergic system function along with the PD progression have yet to be elucidated. Seventy-nine PD patients, including thirty-five early-stage PD patients (PD-E) and forty-four middle-to-late stage PD patients (PD-M), and sixty-four healthy controls (HC) underwent brain magnetic resonance imaging and clinical assessments. We employed seed-based resting-state functional connectivity analysis to explore the cholinergic-related functional alterations. Correlation analysis was used to investigate the relationship between altered functional connectivity and the severity of motor symptoms in PD patients. Results showed that both PD-E and PD-M groups exhibited decreased functional connectivity between left SI and left frontal inferior opercularis areas and increased functional connectivity between left SI and left cingulum middle area as well as right primary motor and sensory areas when comparing with HC. At advanced stages of PD, functional connectivity in the right primary motor and sensory areas was further increased. These altered functional connectivity were also significantly correlated with the Unified Parkinson’s Disease Rating Scale motor scores. In conclusion, this study illustrated that altered cholinergic function plays an important role in the motor disruptions in PD patients both in early stage as well as during the progression of the disease. Frontiers Media S.A. 2021-09-10 /pmc/articles/PMC8461333/ /pubmed/34566625 http://dx.doi.org/10.3389/fnagi.2021.723948 Text en Copyright © 2021 Sheng, Guo, Zhou, Wu, Gao, Pu, Zhang, Zhang, Yang, Guan and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sheng, Wenshuang
Guo, Tao
Zhou, Cheng
Wu, Jingjing
Gao, Ting
Pu, Jiali
Zhang, Baorong
Zhang, Minming
Yang, Yunjun
Guan, Xiaojun
Xu, Xiaojun
Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title_full Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title_fullStr Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title_full_unstemmed Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title_short Altered Cortical Cholinergic Network in Parkinson’s Disease at Different Stage: A Resting-State fMRI Study
title_sort altered cortical cholinergic network in parkinson’s disease at different stage: a resting-state fmri study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461333/
https://www.ncbi.nlm.nih.gov/pubmed/34566625
http://dx.doi.org/10.3389/fnagi.2021.723948
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