Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury

Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve clinical outcomes of cardiovascular disease, which suggests that the regulatory mechanism of PARP1 in cardiovascular disease is unclear. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Naijin, Zhang, Ying, Wu, Boquan, Wu, Shaojun, You, Shilong, Lu, Saien, Liu, Jingwei, Huang, Xinyue, Xu, Jiaqi, Cao, Liu, Sun, Yingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461381/
https://www.ncbi.nlm.nih.gov/pubmed/34555594
http://dx.doi.org/10.1016/j.redox.2021.102141

Ejemplares similares

Ejemplares similares