Cargando…

Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by compu...

Descripción completa

Detalles Bibliográficos
Autores principales: Aaltonen, H Laura, Petersson Sjögren, Madeleine, Jakobsson, Jonas K F, Nicklasson, Hanna, Diaz, Sandra, Sánchez Montiel, Francisco, Zackrisson, Sophia, Ideböhn, Veronica, Engström, Gunnar, Löndahl, Jakob, Wollmer, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461447/
https://www.ncbi.nlm.nih.gov/pubmed/33859054
http://dx.doi.org/10.1136/thoraxjnl-2020-214523
Descripción
Sumario:Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13–1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08–1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.