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Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by compu...

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Autores principales: Aaltonen, H Laura, Petersson Sjögren, Madeleine, Jakobsson, Jonas K F, Nicklasson, Hanna, Diaz, Sandra, Sánchez Montiel, Francisco, Zackrisson, Sophia, Ideböhn, Veronica, Engström, Gunnar, Löndahl, Jakob, Wollmer, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461447/
https://www.ncbi.nlm.nih.gov/pubmed/33859054
http://dx.doi.org/10.1136/thoraxjnl-2020-214523
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author Aaltonen, H Laura
Petersson Sjögren, Madeleine
Jakobsson, Jonas K F
Nicklasson, Hanna
Diaz, Sandra
Sánchez Montiel, Francisco
Zackrisson, Sophia
Ideböhn, Veronica
Engström, Gunnar
Löndahl, Jakob
Wollmer, Per
author_facet Aaltonen, H Laura
Petersson Sjögren, Madeleine
Jakobsson, Jonas K F
Nicklasson, Hanna
Diaz, Sandra
Sánchez Montiel, Francisco
Zackrisson, Sophia
Ideböhn, Veronica
Engström, Gunnar
Löndahl, Jakob
Wollmer, Per
author_sort Aaltonen, H Laura
collection PubMed
description Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13–1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08–1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.
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spelling pubmed-84614472021-10-08 Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema Aaltonen, H Laura Petersson Sjögren, Madeleine Jakobsson, Jonas K F Nicklasson, Hanna Diaz, Sandra Sánchez Montiel, Francisco Zackrisson, Sophia Ideböhn, Veronica Engström, Gunnar Löndahl, Jakob Wollmer, Per Thorax Brief Communication Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13–1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08–1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population. BMJ Publishing Group 2021-10 2021-04-15 /pmc/articles/PMC8461447/ /pubmed/33859054 http://dx.doi.org/10.1136/thoraxjnl-2020-214523 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Aaltonen, H Laura
Petersson Sjögren, Madeleine
Jakobsson, Jonas K F
Nicklasson, Hanna
Diaz, Sandra
Sánchez Montiel, Francisco
Zackrisson, Sophia
Ideböhn, Veronica
Engström, Gunnar
Löndahl, Jakob
Wollmer, Per
Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title_full Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title_fullStr Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title_full_unstemmed Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title_short Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
title_sort airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461447/
https://www.ncbi.nlm.nih.gov/pubmed/33859054
http://dx.doi.org/10.1136/thoraxjnl-2020-214523
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