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Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by compu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461447/ https://www.ncbi.nlm.nih.gov/pubmed/33859054 http://dx.doi.org/10.1136/thoraxjnl-2020-214523 |
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author | Aaltonen, H Laura Petersson Sjögren, Madeleine Jakobsson, Jonas K F Nicklasson, Hanna Diaz, Sandra Sánchez Montiel, Francisco Zackrisson, Sophia Ideböhn, Veronica Engström, Gunnar Löndahl, Jakob Wollmer, Per |
author_facet | Aaltonen, H Laura Petersson Sjögren, Madeleine Jakobsson, Jonas K F Nicklasson, Hanna Diaz, Sandra Sánchez Montiel, Francisco Zackrisson, Sophia Ideböhn, Veronica Engström, Gunnar Löndahl, Jakob Wollmer, Per |
author_sort | Aaltonen, H Laura |
collection | PubMed |
description | Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13–1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08–1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population. |
format | Online Article Text |
id | pubmed-8461447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-84614472021-10-08 Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema Aaltonen, H Laura Petersson Sjögren, Madeleine Jakobsson, Jonas K F Nicklasson, Hanna Diaz, Sandra Sánchez Montiel, Francisco Zackrisson, Sophia Ideböhn, Veronica Engström, Gunnar Löndahl, Jakob Wollmer, Per Thorax Brief Communication Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13–1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08–1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population. BMJ Publishing Group 2021-10 2021-04-15 /pmc/articles/PMC8461447/ /pubmed/33859054 http://dx.doi.org/10.1136/thoraxjnl-2020-214523 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Brief Communication Aaltonen, H Laura Petersson Sjögren, Madeleine Jakobsson, Jonas K F Nicklasson, Hanna Diaz, Sandra Sánchez Montiel, Francisco Zackrisson, Sophia Ideböhn, Veronica Engström, Gunnar Löndahl, Jakob Wollmer, Per Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title | Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title_full | Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title_fullStr | Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title_full_unstemmed | Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title_short | Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
title_sort | airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461447/ https://www.ncbi.nlm.nih.gov/pubmed/33859054 http://dx.doi.org/10.1136/thoraxjnl-2020-214523 |
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