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Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study
End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test–retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size usin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461450/ https://www.ncbi.nlm.nih.gov/pubmed/33632769 http://dx.doi.org/10.1136/thoraxjnl-2020-216078 |
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author | Swift, Andrew J Wilson, Frederick Cogliano, Marcella Kendall, Lindsay Alandejani, Faisal Alabed, Samer Hughes, Paul Shahin, Yousef Saunders, Laura Oram, Charlotte Capener, David Rothman, Alex Garg, Pankaj Johns, Christopher Austin, Matthew Macdonald, Alistair Pickworth, Jo Hickey, Peter Condliffe, Robin Cahn, Anthony Lawrie, Allan Wild, Jim M Kiely, David G |
author_facet | Swift, Andrew J Wilson, Frederick Cogliano, Marcella Kendall, Lindsay Alandejani, Faisal Alabed, Samer Hughes, Paul Shahin, Yousef Saunders, Laura Oram, Charlotte Capener, David Rothman, Alex Garg, Pankaj Johns, Christopher Austin, Matthew Macdonald, Alistair Pickworth, Jo Hickey, Peter Condliffe, Robin Cahn, Anthony Lawrie, Allan Wild, Jim M Kiely, David G |
author_sort | Swift, Andrew J |
collection | PubMed |
description | End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test–retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size using Cohen’s d statistic. Intraclass correlation coefficients demonstrated excellent repeatability for MRI, 6 min walk test and log to base 10 N-terminal pro-brain natriuretic peptide (log(10)NT-proBNP). The treatment effect size for MRI-derived right ventricular ejection fraction was large (Cohen’s d 0.81), whereas the effect size for the 6 min walk test (Cohen’s d 0.22) and log(10)NT-proBNP (Cohen’s d 0.20) were fair. This study supports further evaluation of MRI as a non-invasive end point for clinical assessment and PAH therapy trials. Trial registration number NCT03841344. |
format | Online Article Text |
id | pubmed-8461450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-84614502021-10-08 Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study Swift, Andrew J Wilson, Frederick Cogliano, Marcella Kendall, Lindsay Alandejani, Faisal Alabed, Samer Hughes, Paul Shahin, Yousef Saunders, Laura Oram, Charlotte Capener, David Rothman, Alex Garg, Pankaj Johns, Christopher Austin, Matthew Macdonald, Alistair Pickworth, Jo Hickey, Peter Condliffe, Robin Cahn, Anthony Lawrie, Allan Wild, Jim M Kiely, David G Thorax Brief Communication End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test–retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size using Cohen’s d statistic. Intraclass correlation coefficients demonstrated excellent repeatability for MRI, 6 min walk test and log to base 10 N-terminal pro-brain natriuretic peptide (log(10)NT-proBNP). The treatment effect size for MRI-derived right ventricular ejection fraction was large (Cohen’s d 0.81), whereas the effect size for the 6 min walk test (Cohen’s d 0.22) and log(10)NT-proBNP (Cohen’s d 0.20) were fair. This study supports further evaluation of MRI as a non-invasive end point for clinical assessment and PAH therapy trials. Trial registration number NCT03841344. BMJ Publishing Group 2021-10 2021-02-25 /pmc/articles/PMC8461450/ /pubmed/33632769 http://dx.doi.org/10.1136/thoraxjnl-2020-216078 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Brief Communication Swift, Andrew J Wilson, Frederick Cogliano, Marcella Kendall, Lindsay Alandejani, Faisal Alabed, Samer Hughes, Paul Shahin, Yousef Saunders, Laura Oram, Charlotte Capener, David Rothman, Alex Garg, Pankaj Johns, Christopher Austin, Matthew Macdonald, Alistair Pickworth, Jo Hickey, Peter Condliffe, Robin Cahn, Anthony Lawrie, Allan Wild, Jim M Kiely, David G Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title | Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title_full | Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title_fullStr | Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title_full_unstemmed | Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title_short | Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
title_sort | repeatability and sensitivity to change of non-invasive end points in pah: the respire study |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461450/ https://www.ncbi.nlm.nih.gov/pubmed/33632769 http://dx.doi.org/10.1136/thoraxjnl-2020-216078 |
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